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Name |
2-Methyl-4,6-dinitrophenol |
EINECS | 208-601-1 | |
CAS No. | 534-52-1 | Density | 1.55 g/cm3 | |
PSA | 111.87000 | LogP | 2.56340 | |
Solubility | slightly soluble | Melting Point |
83-85 ºC |
|
Formula | C7H6 N2 O5 | Boiling Point | 332.4 °C at 760 mmHg | |
Molecular Weight | 198.135 | Flash Point | 149.2 °C | |
Transport Information | UN 1598 | Appearance | straw yellow to yellow crystal | |
Safety | Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardiac and gastrointestinal changes. Mutation data reported. An eye and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and 3,5-DINITRO-o-CRESOL; 3,5-DINITRO-p-CRESOL; 2,6-DINITRO-p-CRESOL; 4,6-DINITRO-m-CRESOL; 4,6-DINITRO-o-CRESOL AMMONIUM SALT; 4,6-DINITRO-o-CRESOL BARIUM DERIVATIVE; 4,6-DINITRO-o-CRESOL DIETHYLAMINE SALT; 4,6-DINITRO-o-CRESOL METHYLAMINE (1:1); 4,6-DINITRO-o-CRESOL MORPHOLINE (1:1); 4,6-DINITRO-o-CRESOL SODIUM SALT. | |||
Analytical Methods: | For occupational chemical analysis use NIOSH: Dinitro-o-cresol S166. |
Risk Codes | R26/27/28;R38;R40;R41;R43;R44;R50/53 | |
Molecular Structure | Hazard Symbols | |||
Synonyms |
o-Cresol,4,6-dinitro- (8CI);2,4-Dinitro-6-methylphenol;2-Methyl-4,6-dinitrophenol;3,5-Dinitro-2-hydroxytoluene;4,6-Dinitro-2-methylphenol;4,6-Dinitro-o-cresol;6-Methyl-2,4-dinitrophenol;Antinonin;Antinonnin;Arborol;DNOC;Degrassan;Dekrysil;Detal;Dillex;Dinitro;Dinitrocresol;Dinitrodendtroxal;Dinitrol;Dinoc;Dinurania;Ditrosol;Effusan;Effusan 3436;Elgetol;Elgetol 30;Elipol;Extrar;Flavin-Sandoz;Hedolit;Hedolite;K III;KIV;Kreozan;Krezotol 50;Lipan;NSC 2082;Neudorff DN 50;Nitrofan;Prokarbol;Rafex;Rafex 35;Raphatox;Sandolin;Sandolin A;Selinon;Sinox;Winterwash; |
Article Data | 74 |
Conditions | Yield |
---|---|
With (NH4)2Ce(NO3)6 on pillared bentonite In methanol at 25℃; for 48h; | 100% |
With thionyl chloride; bismuth subnitrate In dichloromethane at 20℃; for 2h; | 83% |
With cupric nitrate trihydrate supported on K 10 montmorillonite clay; nitric acid; acetic anhydride In tetrachloromethane for 1h; Ambient temperature; | 80% |
Conditions | Yield |
---|---|
With zirconyl nitrate In acetone at 20℃; for 0.45h; | A 43% B 52% |
With bismuth(III) nitrate In acetone at 20℃; for 0.0666667h; | A 35% B 45% |
ortho-cresol
A
2-methyl-4-nitrophenol
B
2-methyl-6-nitrophenol
C
2-methyl-4,6-dinitrophenol
Conditions | Yield |
---|---|
With Montmorillonite KSF; nitric acid; hafnium oxychloride In tetrahydrofuran at 20℃; for 16h; | A 36% B 46% C 4% |
With Yb-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h; | A 45% B 39% C 9% |
With Eu-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h; | A 42% B 40% C 9% |
With Montmorillonite KSF; nitric acid; bismuth(III) nitrate In tetrahydrofuran at 20℃; for 16h; | A 26% B 24% C 22% |
With sulfuric acid; calcium(II) nitrate In water at 2℃; for 5h; Product distribution; other substituted phenols; other nitrating agent, var. temp.; |
2-Methyl-4-cyclopropyl-6-nitrophenol
A
2-methyl-4,6-dinitrophenol
B
5,6-Dinitro-2-methyl-4-cyclopropylphenol
C
3-Nitrooxy-1-(3-methyl-4-hydroxy-5-nitrophenyl)-1-propanol
D
3,4,6-Trinitro-2-hydroxy-2-methyl-4-cyclopropyl-5-cyclohexen-1-one
Conditions | Yield |
---|---|
With dinitrogen tetraoxide In dichloromethane at -10℃; for 3h; Product distribution; | A 30% B 18% C 10% D 17% |
Conditions | Yield |
---|---|
anschliessen Behandeln mit 2n-Salpetersaeure; |
2-Methyl-4-t-butylphenol
A
5-Nitro-6-hydroxy-1-methyl-3-tert.-butyl-benzol
B
2-methyl-4,6-dinitrophenol
Conditions | Yield |
---|---|
With nitric acid; benzene |
Conditions | Yield |
---|---|
With nitric acid; acetic acid at -20℃; | |
With nitric acid; benzene unter Kuehlung; |
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid; sodium nitrite at 0℃; | |
Multi-step reaction with 2 steps 1: glacial acetic acid; nitrosylsulfuric acid / -15 - -10 °C 2: diluted nitric acid / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid 2: NaOH-solution View Scheme |
Conditions | Yield |
---|---|
With nitric acid; cis-nitrous acid Erwaermen der erhaltenen Diazoniumsalz-Loesung auf 35-50grad; |
5-Nitro-6-hydroxy-1-methyl-3-tert.-butyl-benzol
2-methyl-4,6-dinitrophenol
Conditions | Yield |
---|---|
With nitric acid |
1. | skn-rbt 105 mg/9D-I MLD | JIHTAB Journal of Industrial Hygiene and Toxicology. 30 (1948),10. | ||
2. | eye-rbt 20 mg/24H MOD | 85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,678. | ||
3. | mma-sat 1 µmol/plate | AIDZAC Aichi Ika Daigaku Igakkai Zasshi. Journal of the Aichi Medical Univ. Assoc. 10 (1982),305. | ||
4. | sln-dmg-orl 250 µmol/L | ARTODN Archives of Toxicology.Suppl. 4(1980),59. | ||
5. | orl-man TDLo:7500 µg/kg/7D:CNS | CMEP** Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1. | ||
6. | ihl-hmn TCLo:1 mg/m3:BRN,CVS,GIT | HYSAAV Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 30 (1965),197. | ||
7. | unr-man LDLo:29 mg/kg | 85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73. | ||
8. | orl-rat LD50:10 mg/kg | 85ARAE Agricultural Chemicals, Books I, II, III, and IV. 3 (1976),54. | ||
9. | skn-rat LD50:200 mg/kg | WRPCA2 World Review of Pest Control. 9 (1970),119. | ||
10. | ipr-rat LDLo:28 mg/kg |
DINITRO-o-CRESOL's Safety Information
Hazard Codes T+,N,T,F
Risk Statements 26/27/28-38-41-43-44-50/53-68-40-39/23/24/25-23/24/25-11-52/53
Safety Statements 36/37-45-60-61-16-7
RIDADR UN 1598 6.1/PG 2
WGK Germany 2
RTECS GO9625000
HazardClass 6.1(a)
PackingGroup II