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Name |
2-Methylaminoethanol |
EINECS | 203-710-0 |
CAS No. | 109-83-1 | Density | 0.89 g/cm3 |
PSA | 32.26000 | LogP | -0.41100 |
Solubility | miscible with water | Melting Point |
-3 °C |
Formula | C3H9NO | Boiling Point | 155.5 °C at 760 mmHg |
Molecular Weight | 75.1106 | Flash Point | 72.8 °C |
Transport Information | UN 2735 8/PG 2 | Appearance | viscous colourless or light yellow liquid |
Safety | 26-36/37/39-45 | Risk Codes | 21/22-34 |
Molecular Structure | Hazard Symbols | C | |
Synonyms |
(2-Hydroxyethyl)methylamine;(Hydroxyethyl)methylamine;2-Hydroxy-N-methylethylamine;2-Hydroxyethyl-N-methylamine;2-Methylamino-1-ethanol;2-N-Monomethylaminoethanol;Amietol M 11;AminoAlcohol MMA;Methyl(2-hydroxyethyl)amine;Methyl(hydroxyethyl)amine;Methyl(b-hydroxyethyl)amine;Methylaminoethanol;Methylethanolamine;Methylethylolamine;Monomethylaminoethanol;Monomethylethanolamine;N-Methyl-N-(2-hydroxyethyl)amine;N-Methylaminoethanol;N-Methylmonoethanolamine;N-Monomethylaminoethanol;N-Monomethylethanolamine;NMEA;NSC 62776;Yubao;b-(Methylamino)ethanol; |
Article Data | 75 |
oxirane
methylamine
A
(2-hydroxyethyl)(methyl)amine
B
N-Methyldiethanolamine
C
2,2'-((1-hydroxypropan-2-yl)azanediyl)bis(ethan-1-ol)
Conditions | Yield |
---|---|
water at 62.84 - 71.84℃; under 7500.75 Torr; for 0.2h; Heating / reflux; | A 16.7% B 83.3% C n/a |
at 66.84 - 76.84℃; under 9000.9 Torr; for 0.116667h; Heating / reflux; | A 63.5% B 36.4% C 0.02% |
water at 61.54 - 63.34℃; under 7500.75 Torr; for 0.2h; Heating / reflux; | |
at 66.34℃; under 9000.9 Torr; for 0.116667h; Heating / reflux; |
Conditions | Yield |
---|---|
With ammonium formate; palladium on activated charcoal In methanol for 0.166667h; Heating; | 83% |
With hydrogen; Pd/C (5percent) In ethanol at 20℃; for 2h; | 67% |
With hydrazine hydrate; palladium on activated charcoal In ethanol for 2h; Heating; | 42% |
4-methyl-1-oxa-4-azaspiro<4.5>decane
A
(2-hydroxyethyl)(methyl)amine
B
1-methyl-4,5,6,7-tetrahydro-1H-indole
C
cyclohexanol
Conditions | Yield |
---|---|
With potassium hydroxide Heating; CH3ONa sa reagent; | A n/a B 72% C n/a |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; ethanolamine With zinc(II) chloride In dichloromethane at 20℃; for 1h; Stage #2: With sodium tetrahydroborate In dichloromethane for 18h; | 72% |
Stage #1: formaldehyd; ethanolamine Stage #2: With sodium tetrahydroborate |
Conditions | Yield |
---|---|
With methyllithium In tetrahydrofuran for 1h; Product distribution; Ambient temperature; further reagents investigated; | 66% |
ethylene glycol
methylamine
A
N,N'-dimethylpiperazine
B
(2-hydroxyethyl)(methyl)amine
C
N,N`-dimethylethylenediamine
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; tris(triphenylphosphine)ruthenium(II) chloride at 130℃; Product distribution; Mechanism; other primary amines, other temperatures, other catalyst; | A 33% B 4% C 44% |
Conditions | Yield |
---|---|
In ethanol; water at 30 - 40℃; | 30% |
Conditions | Yield |
---|---|
With potassium hydroxide; aluminum nickel for 26.1h; | 28% |
methanol
ethanolamine
A
ethyleneimine
B
piperazine
C
1,4-diaza-bicyclo[2.2.2]octane
D
(2-hydroxyethyl)(methyl)amine
Conditions | Yield |
---|---|
With Cs-P-Si mixed-oxide at 300℃; under 750.06 Torr; Title compound not separated from byproducts; | A 37 % Chromat. B n/a C n/a D 6% |
Chemical Name: 2-Methylaminoethanol
IUPAC NAME: 2-(methylamino)ethanol
CAS No.: 109-83-1
Molecular Formula: C3H9NO
Formula Weight: 75.11 g/mol
Structure:
The synonyms of 2-Methylaminoethanol (CAS NO.109-83-1): Methylethanolamine ; N-Methylethanolamine ; N-Methyl(b-hydroxyethyl)mine ; Methylethylolamine ; 2-(Methylamino)ethanol ; (2-Hydroxyethyl)methylamine ; (Hydroxyethyl)methylamine
Polar Surface Area: 32.26 Å2
Index of Refraction: 1.413
Molar Refractivity: 21.07 cm3
Molar Volume: 84.3 cm3
Surface Tension: 29.2 dyne/cm
Enthalpy of Vaporization: 45.68 kJ/mol
Vapour Pressure: 1.1 mmHg at 25°C
Density of 2-Methylaminoethanol (CAS NO.109-83-1): 0.935 g/mL at 25 °C
Boiling Point: 159 °C
Flash Point: 76 °C
Appearance: viscous colourless or light yellow liquid, fishy odor.
Stability: Stable under normal temperatures and pressures. but incompatible with strong oxidizing agents.Combustible.
2-Methylaminoethanol (CAS NO.109-83-1) is used as a chemical intermediate for pharmaceuticals and in textile industry.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | National Technical Information Service. Vol. AD277-689, | |
mouse | LD50 | subcutaneous | 1802mg/kg (1802mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: COMA | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 225, Pg. 428, 1955. |
rabbit | LD50 | skin | 1070uL/kg (1.07mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | National Technical Information Service. Vol. OTS0536158, |
rat | LD50 | intraperitoneal | 1330mg/kg (1330mg/kg) | Toxicology and Applied Pharmacology. Vol. 12, Pg. 486, 1968. | |
rat | LD50 | oral | 1391mg/kg (1391mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Veterinary and Human Toxicology. Vol. 38, Pg. 422, 1996. |
Reported in EPA TSCA Inventory.
Hazard Codes: C
Risk Statements: 21/22-34
R21/22: Harmful in contact with skin and if swallowed.
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2735 8/PG 2
WGK Germany: 1
RTECS: KL6650000
HazardClass: 8
PackingGroup: III
HS Code: 29221980
Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes such as NOx. See also AMINES and ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S..
Storage: Store in a cool, dry place. Keep away from direct sunlight. Keep container closed when not in use.
Handling: Do not ingest or inhale. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.