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2-Nitrophenol (88-75-5)

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 Chemistry
Molecular structure:
Molecular Formula: C6H5NO3
Formula Weight: 139.11
Melting point: 43-45 °C
Boiling point : 214-216 °C
density: 1.495
Vapor pressure : 1 mm Hg ( 49.3 °C)
Flash point : 108 °C
storage temp. : Store in dark!
WATER solubility : 2 g/L (25°C)
Sensitive : Light Sensitive
Appearance:Light yellow
 Uses

2-Nitrophenol is used as  medicine, dyes, rubber chemicals, photosensitive materials and  intermediates.2-Nitrophenol is also used as single-color indicator of PH value.

 Production
The condensation of 2-nitrophenol (I) with 2,2,2-trrifluoroethyl p-toluenesulfonate (II) by means of K2CO3 in DMF gives 2-(2,2,2-trifluoroethoxy) nitrobenzene (III), which isreduced with H2 over PtO2 in ethanol yiedling the aniline (IV). The cyclization of (IV) with bis (2-chloroethyl)amine (V) and K2CO3 affords the piperazine (VI), which is condensed with 1-benzyl-3-(3-chloro-propyl)-5-methylpyrimidine-2,4(1H,3H)-dione (VII) by means of K2CO3 in refluxing acetonitrile to give the benzylated target compound (VIII). Finally, this compound is deprotected by hydrogenation with ammonium formate and Pd/C. The intermediate pyrimidine (VII) has been obtained by benzylation of thymine (IX) with benzyl bromide and K2CO3 to give the 1-benzylthymine (X), which is alkylated with 1-bromo-3-chloropropane and K2CO3 to the target intemediate (VII).
 Safety Profile
Hazard Codes : Xn,T,F
Risk Statements : 22-36/37/38-52/53-33-20/21/22-39/23/24/25-23/24/25-11
Safety Statements : 26-61-45-36/37-16-7-36-28
RIDADR : UN 1663 6.1/PG 3
WGK Germany : 2
RTECS : SM2100000
HazardClass : 6.1
PackingGroup : III
HS Code : 29089000
  • 2-Nitrophenol Basic information

  • Product Name:2-Nitrophenol
  • CAS No:88-75-5
  • Formula:C6H5NO3
  • Molecular Structure of (<span class=bigs><a href=/cas-88/88-75-5.html />88-75-5</a></span>) (o-NITROPHENOL)