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2-Quinoxalinone

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Name

2-Quinoxalinone

EINECS 214-815-6
CAS No. 1196-57-2 Density 1.31 g/cm3
PSA 46.01000 LogP 1.33540
Solubility N/A Melting Point 271-272 °C
Formula C8H6N2O Boiling Point 363.4 °C at 760 mmHg
Molecular Weight 146.148 Flash Point 173.6 °C
Transport Information N/A Appearance N/A
Safety 26-36/39-37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1196-57-2 (2-Quinoxalinone) Hazard Symbols IrritantXi
Synonyms

2-Quinoxalinol(7CI);1,2-Dihydroquinoxalin-2-one;2-Hydroxyquinoxaline;2(1H)-Quinoxalinone;2-Quinoxalone;3-Quinoxalinone;NSC 13154;

Article Data 130

2-Quinoxalinone Chemical Properties

MF: C8H6N2O
MP:271-272°C
MW: 146.146040 g/mol
Flash Point: 173.6 °C
EINECS: 214-815-6
IUPAC
: 1H-quinoxalin-2-one
Product Name: 2-Quinoxalinone
Enthalpy of Vaporization: 63.34 kJ/mol 
Boiling Point: 363.4 °C at 760 mmHg  ]
Vapour Pressure: 8.65E-06 mmHg at 25°C 
Synonyms: 2-quinoxalinol ; 2-Quinoxalinone ; 2-Hydroxyuinoxalin ; Quinoxalin-2-OL ; 1,2-Dihydroquinoxalin-2-one ; 2-(1H)-Quinoxalinone ; 2(1H)-Quinoxalinone ; 2-Quinoxalone
Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinoxalines
CAS DataBase Reference :1196-57-2(CAS DataBase Reference)
Following is the molecular structure of 2-QUINOXALINOL (1196-57-2):

 

2-Quinoxalinone Uses

2-Quinoxalinone (1196-57-2) is an organic phosphorus insecticide parathion quinoline intermediates, is also a pharmaceutical intermediate.

2-Quinoxalinone Toxicity Data With Reference

1.    

ivn-mus LD50:178 mg/kg

    CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#00285 .

2-Quinoxalinone Consensus Reports

Reported in EPA TSCA Inventory.

2-Quinoxalinone Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.
 

Safety Information of 2-Quinoxalinone (1196-57-2):
Hazard Codes:  Xi 
Xi  Irritant 
 Risk Statements : 36/37/38( Irritating to eyes, respiratory system and skin )
Safety Statements : 26-36/39-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;Wear suitable protective clothing and eye/face protection ;Wear suitable gloves and eye/face protection )
RTECS : VD3630000
 

2-Quinoxalinone Analytical Methods

 The Analytical Methods of 2-QUINOXALINOL (1196-57-2):HPLC,NMR

2-Quinoxalinone Specification

The preparation method of 2-QUINOXALINOL (1196-57-2) is based on o-phenylenediamine and chloroacetic acid as starting material, the first synthesis of 2 - hydroxy -  dihydro- Quinoxaline ( hereinafter referred to dihydro- ), and then hydrogen peroxide, to be 2 - Hydroxyquinoxaline. Will chloroacetic acid, water added to the 1000L Enamel Reactor, stirring to dissolve, then add o-phenylenediamine, and constantly stirring, in batches into precipitated calcium carbonate, temperature and reaction some time. Cooling, add sodium hydroxide solution, mixing the material break. Adding hydrogen peroxide, temperature response some time. Serve hot filtered to remove residues, and in the filtrate with concentrated hydrochloric acid, filtration, drying, that is to be 2 - Hydroxyquinoxaline.
Now with the glyoxylic acid line, good quality and high yield.
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