2-Thiophenecarboxylic acid

The 2-Thiophenecarboxylic acid, with the cas registry number527-72-0, has the systematic name of thiophene-2-carboxylic acid. This is a kind of white to light yellow crystal powder, and is soluble in hot water, ethanol, ethyl ether, and slightly soluble in chloroform. Its product categories are various, including thiophenes; aromatic carboxylic acids, amides, anilides, anhydrides & salts; thiophene&benzothiophene; organic acids; heterocyclic compounds; miscellaneous; building blocks; heterocyclic building blocks. As to its usage, it could be used as the intermediate of analgesics anti-inflammatory and the organic synthesis reagents.

The characteristics of this chemical are as follows: (1)ACD/LogP: 1.57; (2)ACD/LogD (pH 5.5): -0.39; (3)ACD/LogD (pH 7.4): -1.5; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1.85; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 54.54; (12)Index of Refraction: 1.606; (13)Molar Refractivity: 31.56 cm³; (14)Molar Volume: 91.4 cm³; (15)Polarizability: 12.51 ×10^-24 cm³; (16)Surface Tension: 58.1 dyne/cm; (17)Density: 1.401 g/cm³; (18)Flash Point: 117.8 °C; (19)Enthalpy of Vaporization: 52.58 kJ/mol; (20)Boiling Point: 260 °C at 760 mmHg; (21)Vapour Pressure: 0.00639 mmHg at 25°C.

Production method of 2-Thiophenecarboxylic acid is as below: thiophene could react to produce 2-Thiophenecarboxylic acid, with the following condition: reagent: mercury diethyl and sodium; other condition: unter Durchleiten von Kohlendioxyd.

Use of 2-Thiophenecarboxylic acid: 2-Thiophenecarboxylic acid reacts to produce thiophene-2-carbonyl chloride, with the following condition: reagent: thionyl chloride; reaction time: 3 hours; other condition: heating.

While dealing with this chemical, you should be very cautious. This is irritating to eyes, respiratory system and skin, and may cause inflammation to the skin or other mucous membranes. You should take the following instructions. Wear suitable protective clothing, gloves and eye/face protection, and ig in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Additionally, the following datas could be converted into the molecular structure:
(1)SMILES:O=C(O)c1sccc1
(2)InChI:InChI=1/C5H4O2S/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)