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Name	2-Thiopheneacetic acid	EINECS	217-639-8
CAS No.	1918-77-0	Density	1.336 g/cm³
PSA	65.54000	LogP	1.37520
Solubility	Soluble in water, ethanol, ether and carbon tetrachloride.	Melting Point	63-64 °C(lit.)
Formula	C₆H₆O₂S	Boiling Point	269.2 °C at 760 mmHg
Molecular Weight	142.178	Flash Point	116.6 °C
Transport Information	UN 3261 8/PG 2	Appearance	white to light yellow crystal powder
Safety	26-36/37/39-45-24/25-27	Risk Codes	34-37-36/37/38
Molecular Structure		Hazard Symbols	C,Xi
Synonyms	2-(2-Thienyl)aceticacid;2-(Thiophen-2-yl)acetic acid;2-Thienylethanoicacid;Thiophen-2-ylacetic acid;	Article Data	51

2-Thiopheneacetic acid Synthetic route

: 57382-97-5
ethyl thiophen-2-ylacetate

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In ethanol at 20℃; for 1h;	100%
With water; sodium hydroxide In ethanol at 20℃; for 1h;	100%

: 5402-55-1
2-thiophenethanol

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With oxygen; triethylamine at 80℃; for 15h; Reagent/catalyst; Temperature;	96.5%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 12h;	85%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Green chemistry;	85%
With iridium hexafluoride; sulphate-doped anatase; potassium oxide In dichloromethane at 85℃; Temperature;

: 19432-68-9
methyl 2-thiopheneacetate

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	94%

: 35320-27-5
2,2,2-trichloro-1-(thien-2-yl)-ethanol

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
Stage #1: 2,2,2-trichloro-1-(thien-2-yl)-ethanol With sodium tetrahydroborate; diphenyl diselenide In ethanol Inert atmosphere; Stage #2: With sodium hydroxide In ethanol at 40℃; Inert atmosphere;	94%

: 20893-30-5
2-cyanomethylthiophene

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 5h; Reflux;	93.4%
With water; potassium hydroxide In ethanol for 3h; Inert atmosphere; Reflux;	74%
With potassium hydroxide

: 89244-23-5, 89244-24-6
N-((E)-1-Cyano-2-thiophen-2-yl-vinyl)-4,N-dimethyl-benzamide

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;	89%

: 5371-94-8
2-methoxy-2-(thiophen-2-yl)acetic acid

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With sodium chloride; iodine In water; acetic acid; ethyl acetate	86%

: 91668-56-3
α-(N-Methylanilino)-β-(2-thienyl)acrylonitrile

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 10h; Heating;	83%

: 15504-41-3
2-oxo-3-(thiophen-2-yl)propanoic acid

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With sodium perborate In water for 48h; Ambient temperature;	68%

: 98-03-3
thiophene-2-carbaldehyde

: 75-25-2
Bromoform

: 75-08-1
ethanethiol

: 1918-77-0
Thiophene-2-acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In diethyl ether; water; dimethyl sulfoxide	58%

2-Thiopheneacetic acid Chemical Properties

IUPAC Name: 2-Thiophen-2-ylacetic acid
Canonical SMILES: C1=CSC(=C1)CC(=O)O
InChI: InChI=1S/C6H6O2S/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2,(H,7,8)
InChIKey: SMJRBWINMFUUDS-UHFFFAOYSA-N
Molecular Weight: 142.17564 [g/mol]
Molecular Formula: C₆H₆O₂S
XLogP3: 1
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 217-639-8
Index of Refraction: 1.587
Molar Refractivity: 35.75 cm³
Molar Volume: 106.3 cm³
Surface Tension: 54.3 dyne/cm
Density: 1.336 g/cm³
Flash Point: 116.6 °C
Enthalpy of Vaporization: 53.59 kJ/mol
Boiling Point: 269.2 °C at 760 mmHg
Vapour Pressure: 0.00363 mmHg at 25 °C
Appearance: white to light yellow crystal powder
Melting Point: 63-64 °C(lit.)
Product Categories: Drug Intermediates; Heterocycles; Thiophene&Benzothiophene; Organic acids; Thiophens; Cephaloridine

2-Thiopheneacetic acid Uses

2-Thiopheneacetic acid (CAS NO.1918-77-0) is used as pharmaceutical intermediates to product cefaloridine, Cefalotin sodium,etc.

2-Thiopheneacetic acid Safety Profile

Safety Information of 2-Thiopheneacetic acid (CAS NO.1918-77-0):
Hazard Codes:C ,Xi
Risk Statements:34-37-36/37/38
34:Causes burns
37:Irritating to the respiratory system
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39-45-24/25-27
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25:Avoid contact with skin and eyes
27:Take off immediately all contaminated clothing
RIDADR:UN 3261 8/PG 2
WGK Germany:3
Hazard Note:Irritant
TSCA:T
HazardClass:8
PackingGroup:III

2-Thiopheneacetic acid Specification

2-Thiopheneacetic acid (CAS NO.1918-77-0), its Synonyms are 2-Thienylacetic acid ; Thiopheneacetic acid ; 2-(2-Thienyl)aceticacid ; 2-(Thiophen-2-yl)acetic acid ; Thiophen-2-ylacetic acid ; 2-Thienylethanoicacid .

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