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Name	3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil	EINECS	N/A
CAS No.	110690-43-2	Density	1.52 g/cm³
PSA	159.58000	LogP	2.53668
Solubility	N/A	Melting Point	162-164°
Formula	C28H19 F N4 O8	Boiling Point	755.1 °C at 760 mmHg
Molecular Weight	558.479	Flash Point	410.5 °C
Transport Information	N/A	Appearance	N/A
Safety	A poison by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and F⁻.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	A poison by ingestion. A reproductive hazard.
Synonyms	BOF-A 2;Emitefur	Article Data	3

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil Chemical Properties

IUPAC Name: (6-Benzoyloxy-3-cyanopyridin-2-yl) 3-[3-(ethoxymethyl)-5-fluoro-2,6-dioxopyrimidine-1-carbonyl]benzoate Synonyms of 3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil (CAS NO.110690-43-2) : 3-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic acid 6-(benzoyloxy)-3-cyano-2-pyridinyl ester ; 3-[3-(6-Benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil ; CNDP ; Emitefur
CAS NO:110690-43-2
Molecular Formula :C₂₈H₁₉FN₄O₈
Molecular Weight :558.47
Molecular Structure :
Index of Refraction:1.663
Surface Tension: 78.8 dyne/cm
Density: 1.52 g/cm³
Flash Point: 410.5 °C
Enthalpy of Vaporization: 110.02 kJ/mol
Boiling Point: 755.1 °C at 760 mmHg
Vapour Pressure: 1.09E-22 mmHg at 25°C
Melting point: 162 ~ 164°C

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil Uses

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil (CAS NO.110690-43-2) is an anticancer drug that belongs to the family of drugs called antimetabolites.

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil Production

Raw materials :N,N-Dimethylformamide-->1,4-Dioxane-->2,6-Dihydroxypyridine-->Isophthaloyl dichloride

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	oral	250mg/kg (250mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN SPLEEN	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 81, 1994.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)	GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN SPLEEN	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 81, 1994.
rat	LD50	oral	1850mg/kg (1850mg/kg)	BLOOD: CHANGES IN SPLEEN SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 81, 1994.
rat	LD50	subcutaneous	250mg/kg (250mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 81, 1994.

3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil Safety Profile

A poison by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When 3-(3-(6-Benzoyloxy-3-cyano-2-pyridyloxy carbonyl)benzoyl)-1-ethoxymethyl-5-fluorouracil (CAS NO:110690-43-2) is heated to decomposition ,it emits toxic vapors of NO_x and F⁻.

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