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3-CHLOROPHENOL
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Name

3-CHLOROPHENOL

 EINECS 203-582-6
CAS No. 108-43-0 Density 1.218 g/cm3
PSA 20.23000 LogP 2.04560
Solubility 27.7 g/L (20 °C) in water Melting Point 31-34 °C(lit.)
Formula C6H5ClO Boiling Point 214 °C at 760 mmHg
Molecular Weight 128.558 Flash Point 76.9 °C
Transport Information UN 2020 6.1/PG 3 Appearance White to light yellow crystal
Safety 28-61-28A Risk Codes 20/21/22-51/53
Molecular Structure Molecular Structure of 108-43-0 (3-Chlorophenol) Hazard Symbols HarmfulXn,DangerousN
Synonyms

Phenol,m-chloro- (7CI,8CI);3-Hydroxychlorobenzene;NSC 59700;m-Chlorophenic acid;m-Chlorophenol;

Article Data 192

3-CHLOROPHENOL Synthetic route

123195-73-3

1-tert-butoxy-3-chlorobenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With sodium iodide; cerium(III) chloride In acetonitrile at 40℃; for 3.5h;100%
24318-02-3

1-(benzyloxy)-3-chlorobenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.0833333h; Microwave irradiation; Inert atmosphere;99%
With triethylsilane; triethylamine; palladium diacetate In dichloromethane at 23℃; for 12h; Hydrogenolysis;
576-24-9

2,3-dichlorophenol

A

108-43-0

3-monochlorophenol

B

108-95-2

phenol

Conditions
ConditionsYield
With 9,10-dihydroanthracene; water at 356.85℃; for 3h; Kinetics;A 99%
B 0.3%
108-37-2

1-bromo-3-chlorobenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In 1,4-dioxane; water at 100℃; for 1h;99%
Multi-step reaction with 2 steps
1: copper dichloride; potassium carbonate / 20 h / 130 °C / Inert atmosphere; Schlenk technique
2: potassium hydroxide / dimethyl sulfoxide / 3 h / 100 °C / Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1: fac-tris(2-phenylpyridinato-N,C2')iridium(III); tributyl-amine; water / acetonitrile / 36 h / 25 °C / Schlenk technique; Inert atmosphere; Sealed tube; Irradiation
2: air / 16 h / 25 °C / Inert atmosphere
View Scheme
With copper(l) iodide; C20H20N4O4; caesium carbonate; Benzaldoxime In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; Glovebox;
63503-60-6

3-chlorophenylboronic acid

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With water In tetrahydrofuran at 100℃; for 12h;99%
With copper(I) oxide; potassium hydroxide In water at 20℃; for 24h; Green chemistry;98%
With copper(II) ferrite; water; sodium hydroxide at 40℃; for 24h; Green chemistry;96%
2655-83-6

1-chloro-3-ethoxybenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.666667h; Microwave irradiation; Inert atmosphere;99%
6161-83-7

2-(3-chlorophenoxy)ethanol

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;99%
625-99-0

3-iodochlorobenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;98%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction;95%
With copper(I) oxide; 2-(N,N-dimethylamino)ethanol; water; potassium hydroxide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;91%
63503-60-6

3-chlorophenylboronic acid

7722-84-1

dihydrogen peroxide

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;97%
1005-41-0

1-chloro-3-vinyloxybenzene

108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;92%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;92%

3-CHLOROPHENOL Chemical Properties

IUPAC:3-chlorophenol
CAS:108-43-0
The Molecular formula of 3-Chlorophenol(108-43-0):C6H5ClO
The Molecular Weight of 3-Chlorophenol(108-43-0):128.56
Synonyms:3-chloro-1-hydroxybenzene;3-chloro-pheno;3-Hydroxychlorobenzene;m-chlorophenicacid;m-chloro-pheno;meta-Chlorophenol;Phenol, m-chloro-;Phenol
EINECS:203-582-6
Density:1.218 g/cm3
Melting Point:33-35oC
Boiling Point:214oC
Flash Point:97oC
Refractive index:n20/D 1.563(lit.)
Water Solubility:27.7 g/L (20oC)
Storage temp.:2-8oC
Stability:Stable.Combustible.Incompatible with acid chlorides,oxidizing agents,acid anhydrides.Discolours in air.
Vapour Pressure:0.109 mmHg at 25oC 
Appearance:white crystalline solid with an unpleasant smell
Product Categories:Organics;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Chlorine Compounds;Phenols;Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites;Organic Building Blocks;Oxygen Compounds
Mol File:108-43-0.mol

3-CHLOROPHENOL Uses

3-Chlorophenol(108-43-0) is widely used in the pharmaceutical, dyes and organic synthesis industry.It is also used as a disinfectant.It is an important intermediate in the synthesis of pesticides such as triadimefon,propaphos,phosazetim.

3-CHLOROPHENOL Toxicity Data With Reference

1.   

mmo-sat 10 µg/plate

   TECSDY    Toxicological and Environmental Chemistry. 14 (1987),143.
2.   

orl-rat LD50:570 mg/kg

   FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
3.   

ipr-rat LD50:355 mg/kg

   BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),20.
4.   

scu-rat LD50:1390 mg/kg

   FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
5.   

orl-mus LD50:521 mg/kg

   TOLED5    Toxicology Letters. 29 (1985),39.

3-CHLOROPHENOL Consensus Reports

Reported in EPA TSCA Inventory. Chlorophenol compounds are on the Community Right-To-Know List.

3-CHLOROPHENOL Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Flammable or combustible liquid. When heated to decomposition it emits toxic fumes of Cl−. See also CHLOROPHENOLS.

Safty informations about 3-Chlorophenol(108-43-0):
Hazard Codes:Xn,N
Risk Statements:20/21/22-51/53
 20/21/22(Harmful by inhalation, in contact with skin and if swallowed)
 51/53(Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Statements:28-61
 28(  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer))
 61(Avoid release to the environment. Refer to special instructions safety data sheet)
RIDADR:UN 2020 6.1/PG 3
WGK Germany:2
RTECS:SK2450000
F:9
HazardClass:6.1
HS Code:29081000

3-CHLOROPHENOL Specification

Handling and Storage:
Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling:Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
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