3-Furanol, tetrahydro-

Reported in EPA TSCA Inventory.

The IUPAC name of 3-Hydroxytetrahydrofuran is oxolan-3-ol. With the CAS registry number 453-20-3, it is also named as 3-Hydroxyoxolane. The product's categories are Alcohols and Derivatives; Heterocycles; Furans; Building Blocks; Heterocyclic Building Blocks, and the other registry number is 84921-89-1. Besides, it is light yellow liquid, which should be stored in sealed, ventilated, dry place away from other oxides. This chemical is stable and incompatible with strong oxidizing agents, acid chlorides, acid anhydrides. In addition, its molecular formula is C₄H₈O₂ and molecular weight is 88.11.

The other characteristics of this product can be summarized as: (1)EINECS: 207-219-2; (2)ACD/LogP: -0.83; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -0.83; (5)ACD/LogD (pH 7.4): -0.83; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 8.45; (9)ACD/KOC (pH 7.4): 8.45; (10)#H bond acceptors: 2; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.475; (14)Molar Refractivity: 21.64 cm³; (15)Molar Volume: 76.7 cm³; (16)Surface Tension: 38.7 dyne/cm; (17)Density: 1.148 g/cm³; (18)Flash Point: 81.1 °C; (19)Enthalpy of Vaporization: 48.57 kJ/mol; (20)Boiling Point: 181 °C at 760 mmHg; (21)Vapour Pressure: 0.255 mmHg at 25 °C.

Preparation of 3-Hydroxytetrahydrofuran: this chemical can be prepared by But-3-en-1-ol.



This reaction needs aq. H₂O₂ and Titanium silicate-1 at temperature of 24.9 °C. The reaction time is 18 hours. The yield is 82 %.

Uses of 3-Hydroxytetrahydrofuran: this chemical can be used in organic synthesis. Similarly, it can react with Benzoyl chloride to get 3-Benzoyloxytetrahydrofuran.



This reaction needs Pyridine at temperature of 10 °C for 10 hours. The yield is 82 %.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)SMILES: OC1CCOC1
(2)InChI: InChI=1/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2
(3)InChIKey: XDPCNPCKDGQBAN-UHFFFAOYAL

The toxicity data is as follows: