Benzoic acid,4-amino-2-hydroxy-

The 4-Aminosalicylic acid, with the CAS registry number 65-49-6, is also known as Aminosalicylic Acid. It belongs to the product categories of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organic Acids; Hematology and Histology; Histology Special Stains; Electrophoresis of Glycans Stains and Dyes; Glycan Labeling and Analysis; Glycobiology; S; Stains & Dyes, A to; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 200-613-5. This chemical's molecular formula is C₇H₇NO₃ and molecular weight is 153.14. What's more, both its IUPAC name and systematic name are the same which is called 4-Amino-2-hydroxybenzoic acid. It should be stored in a sealed place and avoid light. It is manufactured by the carboxylation of 3-aminophenol. This chemical is an antibiotic used to treat tuberculosis.

Physical properties about 4-Aminosalicylic acid are: (1)ACD/LogP: 1.242; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.36; (4)ACD/LogD (pH 7.4): -1.89; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 83.55 Å²; (13)Index of Refraction: 1.691; (14)Molar Refractivity: 39.301 cm³; (15)Molar Volume: 102.673 cm³; (16)Polarizability: 15.58×10^-24 cm³; (17)Surface Tension: 83.37 dyne/cm; (18)Density: 1.492 g/cm³; (19)Flash Point: 184.076 °C; (20)Enthalpy of Vaporization: 66.344 kJ/mol; (21)Boiling Point: 380.758 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

Uses of This reaction needs solvent diethyl ether at temperature of 25 °C. The reaction time is 25 min. The yield is 100 %.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health at low levels and it may cause inflammation to the skin or other mucous membranes. In addition, it is toxic by inhalation, in contact with skin and if swallowed. The product is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell you should seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(O)c1ccc(cc1O)N
(2) InChI: InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
(3) InChIKey: WUBBRNOQWQTFEX-UHFFFAOYSA-N

The toxicity data is as follows: