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With the CAS registry number 824959-81-1, JWH-210 is an analgesic chemical with the formula C26H27NO. The IUPAC name of this chemical is 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081. In addition, JWH-210 is white powder from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It was discovered and named after Dr. John W. Huffman.
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