Basic information
- Name:
Phenol,4-amino-
- Superlist Name:
- 4-Aminophenol
- CAS No.:
123-30-8
- Molecular Structure:

- Formula:
- C6H7NO
- Synonyms:
- Phenol,p-amino- (8CI);1-Amino-4-hydroxybenzene;4-Amino-1-hydroxybenzene;4-Hydroxy-1-aminobenzene;4-Hydroxyaniline;4-Hydroxybenzenamine;4-Hydroxyphenylamine;Activol;Azol;BASF Ursol P Base;Benzofur P;C.I. 76550;C.I. Oxidation Base 6;Certinal;Citol;Durafur Brown RB;Fouramine P;Fourrine84;Fourrine P Base;Furro P base;NSC 1545;Nako Brown R;Paranol;PelagolGrey P Base;Pelagol P Base;Renal AC;Rodinal;Tertral P Base;Unal;Ursol P;Ursol P Base;Zoba Brown P Base;p-Aminophenol;p-Hydroxyaniline;p-Hydroxyphenylamine;p-Amino phenol;4-Aminophenol, para amino phenol;
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Chemistry
Molecular formula: C6H7NO
Molar mass: 109.13 g/mol
EINECS: 204-616-2
Index of Refraction: 1.637
Molar Refractivity: 32.37 cm3
Molar Volume: 90.1 cm3
Surface Tension: 57.4 dyne/cm
Density: 1.21 g/cm3
Flash Point: 124.3 °C
Enthalpy of Vaporization: 54.17 kJ/mol
Boiling Point: 282 °C at 760 mmHg
Vapour Pressure: 0.00202 mmHg at 25 °C
Melting point: 188 °C
Storage tempreture: Refrigerator
Water solubility: 1.5 g/100 mL (20 °C)
Appearance: Off white granular powder
Structure of 4-Aminophenol (CAS NO.123-30-8):
![]()
IUPAC Name: 4-Aminophenol
Canonical SMILES: C1=CC(=CC=C1N)O
InChI: InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
InChIKey: PLIKAWJENQZMHA-UHFFFAOYSA-N
Product Category of 4-Aminophenol (CAS NO.123-30-8): Aromatic Phenols;API intermediates;Phenols (Building Blocks for Liquid Crystals);Anilines (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Functional Materials
Uses
4-Aminophenol (CAS NO.123-30-8) is commonly used as a developer in black and white film, marketed under the name Rodinal.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 56200ug/kg (56.2mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| cat | LDLo | subcutaneous | 37mg/kg (37mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913. |
| guinea pig | LDLo | subcutaneous | 1500mg/kg (1500mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 401, 1895. | |
| mammal (species unspecified) | LD50 | oral | 1530mg/kg (1530mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980. | |
| mammal (species unspecified) | LD50 | skin | 6400mg/kg (6400mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980. | |
| mammal (species unspecified) | LD50 | unreported | 563mg/kg (563mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 19, 1983. | |
| mouse | LD50 | unreported | 750mg/kg (750mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985. | |
| mouse | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952. | |
| mouse | LDLo | subcutaneous | 470mg/kg (470mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 188, Pg. 130, 1938. | |
| rabbit | LD50 | oral | 10gm/kg (10000mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956. | |
| rabbit | LD50 | skin | > 10gm/kg (10000mg/kg) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973, | |
| rat | LC50 | inhalation | > 5mg/m3/1H (5mg/m3) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973, | |
| rat | LD50 | intraperitoneal | 465mg/kg (465mg/kg) | BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 31, 1944. |
| rat | LD50 | oral | 375mg/kg (375mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CYANOSIS | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973, |
| rat | LD50 | unreported | 675mg/kg (675mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985. |
Consensus Reports
Related aminophenols 2-Aminophenol 3-Aminophenol
Related compounds Aniline Phenol
Safety Profile
Hazard Codes:
Xn,
N
The Risk Statements information of 4-aminophenol :
40: Limited evidence of a carcinogenic effect
68: Possible risk of irreversible effects
20/22: Harmful by inhalation and if swallowed
50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
The Safety Statements information of 4-aminophenol:
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
60: This material and/or its container must be disposed of as hazardous waste
61: Avoid release to the environment. Refer to special instructions safety data sheet
36/37: Wear suitable protective clothing and gloves
RIDADR:UN 2512 6.1/PG 3
WGK Germany:3
Specification
4-Aminophenol , its cas register number is 123-30-8. It also can be called 4-Amino-1-hydroxybenzene ; 4-Hydroxyaniline ; and 1-Amino-4-hydroxybenzene . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Get medical aid. Wash mouth out with water. Notes to physician: Treat supportively and symptomatically.
In addition, 4-Aminophenol (CAS NO.123-30-8) may discolor on exposure to air and light.. It is not compatible with strong oxidizing agents, acids, bases, acid chlorides, acid anhydrides, chloroformates, and you must not take it with incompatible materials, light, exposure to a. And also prevent it to broken down into hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide.
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