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Basic information

  • Name:
  • Phenol,4-amino-

  • Superlist Name:
  • 4-Aminophenol
  • CAS No.:
  • 123-30-8

  • Formula:
  • C6H7NO
  • Synonyms:
  • Phenol,p-amino- (8CI);1-Amino-4-hydroxybenzene;4-Amino-1-hydroxybenzene;4-Hydroxy-1-aminobenzene;4-Hydroxyaniline;4-Hydroxybenzenamine;4-Hydroxyphenylamine;Activol;Azol;BASF Ursol P Base;Benzofur P;C.I. 76550;C.I. Oxidation Base 6;Certinal;Citol;Durafur Brown RB;Fouramine P;Fourrine84;Fourrine P Base;Furro P base;NSC 1545;Nako Brown R;Paranol;PelagolGrey P Base;Pelagol P Base;Renal AC;Rodinal;Tertral P Base;Unal;Ursol P;Ursol P Base;Zoba Brown P Base;p-Aminophenol;p-Hydroxyaniline;p-Hydroxyphenylamine;p-Amino phenol;4-Aminophenol, para amino phenol;
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Chemistry

Molecular formula: C6H7NO
Molar mass: 109.13 g/mol 
EINECS: 204-616-2 
Index of Refraction: 1.637
Molar Refractivity: 32.37 cm3
Molar Volume: 90.1 cm3
Surface Tension: 57.4 dyne/cm
Density: 1.21 g/cm3
Flash Point: 124.3 °C
Enthalpy of Vaporization: 54.17 kJ/mol
Boiling Point: 282 °C at 760 mmHg
Vapour Pressure: 0.00202 mmHg at 25 °C
Melting point: 188 °C
Storage tempreture: Refrigerator
Water solubility: 1.5 g/100 mL (20 °C)
Appearance: Off white granular powder
Structure of 4-Aminophenol (CAS NO.123-30-8):
                     
IUPAC Name: 4-Aminophenol
Canonical SMILES: C1=CC(=CC=C1N)O
InChI: InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
InChIKey: PLIKAWJENQZMHA-UHFFFAOYSA-N
Product Category of 4-Aminophenol (CAS NO.123-30-8): Aromatic Phenols;API intermediates;Phenols (Building Blocks for Liquid Crystals);Anilines (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Functional Materials

Uses

 4-Aminophenol (CAS NO.123-30-8) is commonly used as a developer in black and white film, marketed under the name Rodinal.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 56200ug/kg (56.2mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LDLo subcutaneous 37mg/kg (37mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913.
guinea pig LDLo subcutaneous 1500mg/kg (1500mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 401, 1895.
mammal (species unspecified) LD50 oral 1530mg/kg (1530mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 skin 6400mg/kg (6400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 unreported 563mg/kg (563mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 19, 1983.
mouse LD50 unreported 750mg/kg (750mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985.
mouse LDLo intraperitoneal 100mg/kg (100mg/kg)   Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.
mouse LDLo subcutaneous 470mg/kg (470mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 188, Pg. 130, 1938.
rabbit LD50 oral 10gm/kg (10000mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956.
rabbit LD50 skin > 10gm/kg (10000mg/kg)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LC50 inhalation > 5mg/m3/1H (5mg/m3)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LD50 intraperitoneal 465mg/kg (465mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 31, 1944.
rat LD50 oral 375mg/kg (375mg/kg) BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LD50 unreported 675mg/kg (675mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985.

Consensus Reports

Related aminophenols  2-Aminophenol 3-Aminophenol
Related compounds     Aniline Phenol

Safety Profile

Hazard Codes:   Xn,   N
The Risk Statements information of  4-aminophenol :
40:  Limited evidence of a carcinogenic effect 
68:  Possible risk of irreversible effects 
20/22:  Harmful by inhalation and if swallowed 
50/53:  Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
The Safety Statements information of  4-aminophenol:
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 
60:  This material and/or its container must be disposed of as hazardous waste 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
36/37:  Wear suitable protective clothing and gloves 
RIDADR:UN 2512 6.1/PG 3
WGK Germany:3

Specification

 4-Aminophenol , its cas register number is 123-30-8. It also can be called 4-Amino-1-hydroxybenzene ; 4-Hydroxyaniline ; and 1-Amino-4-hydroxybenzene . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Get medical aid. Wash mouth out with water. Notes to physician: Treat supportively and symptomatically.
In addition, 4-Aminophenol (CAS NO.123-30-8) may discolor on exposure to air and light.. It is not compatible with strong oxidizing agents, acids, bases, acid chlorides, acid anhydrides, chloroformates, and you must not take it with incompatible materials, light, exposure to a. And also prevent it to broken down into hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide.

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