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Cas Database |
| Name |
5'-O-dimethoxytrityl-deoxythymidine |
EINECS | 255-003-1 |
| CAS No. | 40615-39-2 | Density | 1.272 g/cm3 |
| PSA | 112.01000 | LogP | 3.51930 |
| Solubility | 3mg/L at 20℃ | Melting Point |
114-116 °C (subl.)(lit.) |
| Formula | C31H32N2O7 | Boiling Point | 618.41°C (rough estimate) |
| Molecular Weight | 544.604 | Flash Point | N/A |
| Transport Information | N/A | Appearance | White powder |
| Safety | 26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Thymidine,5'-O-[a,a-bis(p-methoxyphenyl)benzyl]- (7CI);5'-O-(4,4'-Dimethoxytrityl)-2'-deoxythymidine;5'-O-(4,4'-Dimethoxytrityl)thymidine;5'-O-(Di-p-methoxytrityl)thymidine;5'-O-(p,p'-Dimethoxytrityl)thymidine; |
Article Data | 163 |
5'-O-dimethoxytrityl-deoxythymidine Synthetic route
- 40615-36-9
4,4'-dimethoxytrityl chloride
- 50-89-5
thymidine
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With pyridine; dmap at 20℃; for 5h; | 97% |
| With pyridine; dmap at 20℃; for 24h; | 96% |
| With pyridine at 20℃; for 12h; | 96% |
- 289712-59-0
2-Azidomethyl-benzoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With diphenyl(methyl)phosphine In 1,4-dioxane; water at 20℃; for 0.25h; Product distribution; Further Variations:; Catalysts; Reaction partners; Reagents; Solvents; reaction times; | 96% |
- 50-89-5
thymidine
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With 2,6-di-tert-butyl-4-methylpyridine In nitromethane at 20℃; for 17h; or pyridine, other solvents; | 93% |
| With lithium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Heating; | 74% |
- 40615-36-9
4,4'-dimethoxytrityl chloride
- 50-89-5
thymidine
A
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
B
- 52417-09-1
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine
| Conditions | Yield |
|---|---|
| With pyridine at 20℃; for 1.5h; | A 93% B n/a |
| With pyridine at 20℃; for 1.5h; | A 93% B n/a |
| With pyridine at 20℃; for 1.5h; | A 93% B n/a |
- 110-86-1
pyridine
- 40615-36-9
4,4'-dimethoxytrityl chloride
- 50-89-5
thymidine
A
- 847699-97-2
benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester
B
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| at 20℃; for 1.5h; | A n/a B 93% |
- 40615-36-9
4,4'-dimethoxytrityl chloride
A
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
B
- 52417-09-1
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine
| Conditions | Yield |
|---|---|
| With pyridine at 20℃; for 0.5h; | A 93% B n/a |
| With pyridine at 20℃; for 1.5h; | A 93% B n/a |
- 342890-03-3
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
A
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| In methanol for 0.75h; Irradiation; | A n/a B 92% |
| In methanol for 0.75h; Irradiation; | A 92% B 91% |
- 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With pivaloyl chloride; ethylene glycol at 0℃; for 0.333333h; Hydrolysis; | 91% |
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With tri-n-butyl-tin hydride In toluene at 115℃; for 0.0833333h; | 82% |
- 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran; water for 3h; Ambient temperature; | 73% |
5'-O-dimethoxytrityl-deoxythymidine Chemical Properties
Molecular Structure of 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):
IUPAC Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
Cas register number: 40615-39-2
Molecular formula: C31H32N2O6
Molecular Weight: 528.6
Density: 1.272 g/cm3
Index of Refraction: 1.602
Molar Refractivity: 146.9 cm3
Molar Volume: 427.8 cm3
Polarizability: 58.23×10-24cm3
Surface Tension: 51.6 dyne/cm
Appearance: White Powder
Product Categories: Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides.
5'-O-dimethoxytrityl-deoxythymidine Safety Profile
Safety Statements about 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):
Hazard Codes:
Xi:
R36/37/38: Irritating to eyes, respiratory system and skin.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
F1: Sensitive to air and humidity.
F3: Hygroscopic.
F10: Keep under argon.
WGK Germany: 3
Hazard Note: Irritant
5'-O-dimethoxytrityl-deoxythymidine Specification
5'-O-dimethoxytrityl-deoxythymidine , its cas register number is 40615-39-2. It also can be called 5’-O-[bis(4-methoxyphenyl)phenylmethyl]-thymidin ; 5'-Dimethoxytrityl thymidine ; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine ; 5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine ; 5'-O-(4,4'-dimethoxytrityl)thymidine ; 5-O-(4,4-dimethoxytrityl)thymidine ; 5'-O-dimethoxytrityl-deoxythymidine ; 5'-O-(dimethoxytrityl)-thymidine . Some useful informationabout Handling and Storage: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.Keep refrigerated. (Store below 4°C/39°F.) Keep container closed when not in use. Store in a dry area.
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