- Name
5-Chloro-2-methylaniline
- EINECS202-452-6
- CAS No.
95-79-4
- Density1.18 g/cm3
- PSA26.02000
- LogP2.81180
- Solubility< 1 g/L (22 °C) in water
- Melting Point22 °C
- FormulaC7H8ClN
- Boiling Point237 °C at 760 mmHg
- Molecular Weight141.6
- Flash Point160 °C
- Transport InformationUN 3429 6.1/PG 3
- Appearanceclear yellow to light brown liquid after melting
- Safety26-45-36/37/39-53
- Risk Codes22-36/37/38-40-45-23/24/25
- Molecular Structure
- Hazard SymbolsXn, T
- SynonymsXn, T
- Article Data24
5-Chloro-2-methylaniline Chemical Properties
Molecular Formula:C
7H
8ClN
Molar mass:141.59812g/mol
Structure of 5-Chloro-2-methylaniline(95-79-4):
Synonyms of 5-Chloro-2-methylaniline(95-79-4):5-Chloro-o-toluidine;1-Amino-3-chloro-6-methylbenzene;4-chloro-2-aminotoluene[qr];2-amino-4-chlorotoluene[qr];2-Methyl-5-chloroaniline;3-chloro-6-methylaniline[qr]
Density:1.18 g/cm
3 Flash Point:160 °C
Boiling Point:237 °C at 760 mmHg
Index of Refraction:1.585
Vapour Pressure:0.0459 mmHg at 25°C
Melting point:22°C
Water solubility:< 1 g/L (22°C)
Solubility:soluble in ethanol, ether and other organic solvents alkaline solution.
Appearance:Solid off-white or light brown oily liquid
5-Chloro-2-methylaniline Uses
5-Chloro-2-methylaniline(95-79-4) can be a direct synthesis of azoic dyes red-based KB and Naphthol AS-KB in dyestuff industry, and also is an important pesticide intermediates.
5-Chloro-2-methylaniline Toxicity Data With Reference
1. | | dni-mus-orl 200 mg/kg | | MUREAV Mutation Research. 46 (1977),305. |
2. | | orl-rat LD50:464 mg/kg | | NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) NIH-NCI-E-C-72-3252 . |
4. dog LDLo oral > 100mg/kg (100mg/kg)
"Pesticide Index," Frear, E.H., ed., State College, 5.PA, College Science Pub., 1969Vol. 4, Pg. 113, 1969. domestic animals - goat/sheep LDLo oral > 200mg/kg (200mg/kg)
"Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 4, Pg. 113, 1969.
6. rat LD50 oral 464mg/kg (464mg/kg)
Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973.
7. Carcinogenicity:5-Chloro-2-methylaniline(95-79-4)- Not listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65.
Other: See actual entry in RTECS for complete information.Mutagenicity: Ames-test: negative.The toxicological properties have not been fully investigated.
5-Chloro-2-methylaniline Consensus Reports
NTP Carcinogenesis Bioassay (feed): Clear Evidence: mouse NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-187 ,1979. ; (feed): Inadequate Studies: rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-187 ,1979. . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
5-Chloro-2-methylaniline Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl
− and NO
x. See also AROMATIC AMINES.
Hazard Codes:Xn
,T
Risk Statements:
22: Harmful if swallowed
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
45: May cause cancer
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
5-Chloro-2-methylaniline Standards and Recommendations
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification: 6.1; Label: KEEP AWAY FROM FOOD
5-Chloro-2-methylaniline Specification
Stability and Reactivity of 5-Chloro-2-methylaniline(95-79-4):
Conditions to Avoid:Incompatible materials,light.
Incompatibilities with Other Materials:Strong oxidizing agents, chloroformates, acids, acid anhydrides, acid chlorides.
Hazardous Decomposition Products: Carbon dioxide, nitrogen oxides,hydrogen chloride, carbon monoxide.