Reported in EPA TSCA Inventory.

1. Introduction of 5-Chloro-8-hydroxyquinoline
5-Chloro-8-hydroxyquinoline, with the CAS registry number 130-16-5, is also known as Cloxiquine. It belongs to the product categories of Quinolines, Quinazolines and derivatives; Quinolines; Haloquinolines; Hydroxyquinolines; Pesticide Intermediates. Its EINECS registry number is 204-978-1. Its IUPAC name is called 5-chloroquinolin-8-ol. 5-Chloro-8-hydroxyquinoline is light green to grey powder which can be used in organic synthesis. In addition, its classification codes are Antibacterial; Mutation data.

2. Properties of 5-Chloro-8-hydroxyquinoline
(1)ACD/LogP: 3.02; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.19; (4)ACD/LogD (pH 7.4): 2.17; (5)ACD/BCF (pH 5.5): 17.09; (6)ACD/BCF (pH 7.4): 16.46; (7)ACD/KOC (pH 5.5): 153.88; (8)ACD/KOC (pH 7.4): 148.24; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.696; (13)Molar Refractivity: 48.96 cm³; (14)Molar Volume: 127.1 cm³; (15)Surface Tension: 61.5 dyne/cm; (16)Density: 1.412 g/cm³; (17)Flash Point: 164.7 °C; (18)Enthalpy of Vaporization: 61.65 kJ/mol; (19)Boiling Point: 348.7 °C at 760 mmHg; (20)Vapour Pressure: 2.46E-05 mmHg at 25°C.

3. Structure Descriptors of 5-Chloro-8-hydroxyquinoline
(1)Canonical SMILES: C1=CC2=C(C=CC(=C2N=C1)O)Cl
(2)InChI: InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
(3)InChIKey: CTQMJYWDVABFRZ-UHFFFAOYSA-N

4. Toxicity of 5-Chloro-8-hydroxyquinoline

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	oral	1200mg/kg (1200mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 28, Pg. 484, 1931.

5. Safety Information of 5-Chloro-8-hydroxyquinoline
Hazard Symbols:Xi
Risk Codes:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S24/25:Avoid contact with skin and eyes.

6. Preparation of 5-Chloro-8-hydroxyquinoline
The 5-Chloro-8-quinolinol can be prepared by 5-bromo-quinolin-8-ol. This reaction will need reagent pyridine hydrochloride. The reaction time is 10 min with reaction temperature of 220 ℃. The yield is about 93%.

7. Use of 5-Chloro-8-hydroxyquinoline
5-Chloro-8-quinolinol can be used to produce 5-chloro-7-(3,6,12,15-tetraoxa-9,21-diaza-bicyclo[15.3.1]heneicosa-1(20),17(21),18-trien-9-ylmethyl)-quinolin-8-ol by heating. This reaction need solvent benzene with reaction time of 12 hours. The yield is about 58%.

8. Other details of 5-Chloro-8-hydroxyquinoline
When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. You should avoid contacting it with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.