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5-Ethyl-2-vinylpyridine

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Name

5-Ethyl-2-vinylpyridine

EINECS 226-475-6
CAS No. 5408-74-2 Density 0.941 g/cm3
PSA 12.89000 LogP 2.28700
Solubility N/A Melting Point N/A
Formula  C9H11 N Boiling Point 208.5ºC at 760 mmHg
Molecular Weight 133.193 Flash Point 76.2 ºC
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 5408-74-2 (5-ETHYL-2-VINYL PYRIDINE) Hazard Symbols N/A
Synonyms

Pyridine,5-ethyl-2-vinyl- (6CI,7CI,8CI);5-Ethyl-2-vinylpyridine;NSC 8395;

Article Data 13

5-Ethyl-2-vinylpyridine Synthetic route

646519-88-2

5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione

A

5408-74-2

5-ethyl-2-vinyl-pyridine

B

105355-27-9

Pioglitazone

C

74772-78-4

5-(4-hydroxybenzyl)-2,4-thiazolidinedione

Conditions
ConditionsYield
With acetic acid; zinc In ethyl acetate at 25 - 35℃; for 9h; Product distribution / selectivity;A n/a
B 41%
C n/a
With acetic acid; zinc at 25 - 30℃; for 15h;A 10%
B 25%
C 12%
Stage #1: 5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione With acetic acid; zinc at 5 - 30℃; for 15h;
Stage #2: With sodium carbonate In water; acetic acid Product distribution / selectivity;
A 10%
B 20%
C 12%
104-90-5

5-ethyl-2-methyl-pyridine

50-00-0

formaldehyd

A

5408-74-2

5-ethyl-2-vinyl-pyridine

B

5223-06-3

5-ethyl-2-(2-hydroxyethyl)pyridine

Conditions
ConditionsYield
With dipotassium peroxodisulfate; ethanol at 220℃;
In water at 155℃; under 4500.45 Torr; for 4h; Pressure; Autoclave;A n/a
B 70 g
5223-06-3

5-ethyl-2-(2-hydroxyethyl)pyridine

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
With aluminum oxide at 420℃;
With potassium hydroxide at 175℃; Erhitzen unter vermindertem Druck;
With potassium hydroxide Heating; Yield given;
7647-01-0

hydrogenchloride

5223-06-3

5-ethyl-2-(2-hydroxyethyl)pyridine

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
at 160 - 170℃; nachfolgenden Erwaermen mit Natronlauge;
5-ethyl-2-<β-oxy-ethyl>-pyridine

5-ethyl-2-<β-oxy-ethyl>-pyridine

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
With hydrogenchloride at 160 - 170℃; im Rohr; Erwaermen mit Natronlauge;
With hydrogenchloride at 160 - 170℃; im Rohr; Destillieren ueber Kaliumhydroxyd;
5223-06-3

5-ethyl-2-(2-hydroxyethyl)pyridine

potassium hydroxide

potassium hydroxide

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
Destillation;
104-90-5

5-ethyl-2-methyl-pyridine

pyridine-homologous/ues

pyridine-homologous/ues

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: formic acid, tert-butylcatechol / ethanol / 120 h / Heating
2: KOH / Heating
View Scheme
104-90-5

5-ethyl-2-methyl-pyridine

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium peroxo disulfate; ethanol / 220 °C
2: potassium hydroxide / 175 °C / Erhitzen unter vermindertem Druck
View Scheme
Multi-step reaction with 2 steps
1: formic acid; water / 240 °C / 139011 Torr
2: potassium hydroxide / 175 °C / Erhitzen unter vermindertem Druck
View Scheme
Multi-step reaction with 3 steps
1: water / 3 h / 150 - 160 °C / 3750.38 - 4500.45 Torr / Autoclave
2: triethylamine; p-toluenesulfonyl chloride / toluene / 0 - 5 °C
3: potassium carbonate / toluene / 10 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: water / 4 h / 155 °C / 4500.45 Torr / Autoclave
2: triethylamine; p-toluenesulfonyl chloride / toluene / 0 - 5 °C
3: potassium carbonate / toluene / 10 h / Reflux
View Scheme
646519-89-3

5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione hydrochloride

A

5408-74-2

5-ethyl-2-vinyl-pyridine

B

105355-27-9

Pioglitazone

C

74772-78-4

5-(4-hydroxybenzyl)-2,4-thiazolidinedione

Conditions
ConditionsYield
With acetic acid; zinc In methanol Product distribution / selectivity; Industry scale;
768-61-6

2-hydroxymethyl-5-ethyl pyridine

5408-74-2

5-ethyl-2-vinyl-pyridine

Conditions
ConditionsYield
With potassium hydroxide

5-Ethyl-2-vinylpyridine Chemical Properties

IUPAC Name:   2-Ethenyl-5-ethylpyridine
Synonyms: Pyridine 2-vinyl-5-ethyl- ; 3-Ethyl-6-vinylpyridine ; 5-Ethyl-2-vinyl-pyridin ; 2-Vinyl-5-ethylpyridine
The Molecular Formula of  5-Ethyl-2-vinylpyridin (5408-74-2) : C9H11N
The Molecular Weight of   5-Ethyl-2-vinylpyridin (5408-74-2):133.190340g/mol
The Molecular Structure of   5-Ethyl-2-vinylpyridin (5408-74-2):
Index of Refraction: 1.546
Molar Refractivity: 44.81 cm3
Molar Volume: 141.4 cm3
Surface Tension: 34.5 dyne/cm
Density: 0.941 g/cm3 
Flash Point: 76.2 °C
Enthalpy of Vaporization: 42.66 kJ/mol
Boiling Point: 208.5 °C at 760 mmHg
Vapour Pressure: 0.307 mmHg at 25°C 

5-Ethyl-2-vinylpyridine Uses

    5-Ethyl-2-vinylpyridin (5408-74-2) can be used for bioactivity analysis.

5-Ethyl-2-vinylpyridine Toxicity Data With Reference

1.    

skn-rbt 10 mg/24H open

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
2.    

skn-rbt 5 mg/24H SEV

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,847.
3.    

eye-rbt 20 mg open

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.    

eye-rbt 100 mg/24H MOD

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,847.
5.    

orl-rat LD50:1230 mg/kg

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
6.    

ihl-rat LCLo:8000 ppm/4H

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
7.    

skn-rbt LD50:890 mg/kg

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.

5-Ethyl-2-vinylpyridine Safety Profile

Moderately toxic by ingestion and skin contact. Mildly toxic by inhalation. An eye and severe skin irritant. When heated to decomposition it emits toxic fumes of NOx.

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