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Cas Database |
| Name |
5-Methyl-2-pyrazinecarboxylic acid |
EINECS | 413-260-9 |
| CAS No. | 5521-55-1 | Density | 1.319 g/cm3 |
| PSA | 63.08000 | LogP | 0.48320 |
| Solubility | N/A | Melting Point |
167-171 °C(lit.) |
| Formula | C6H6N2O2 | Boiling Point | 316.5 °C at 760 mmHg |
| Molecular Weight | 138.126 | Flash Point | 145.2 °C |
| Transport Information | N/A | Appearance | Pale Brown Powder |
| Safety | 26-39-36 | Risk Codes | 41-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2-Pyrazinecarboxylicacid, 5-methyl-;Pyrazinecarboxylic acid, 5-methyl- (7CI,8CI,9CI);2-Methylpyrazine-5-carboxylic acid;5-Methyl-2-pyrazinoic acid;5-Methylpyrazine carboxylic acid;5-Methylpyrazine-2-Carboxylic Acid; |
Article Data | 17 |
5-Methyl-2-pyrazinecarboxylic acid Synthetic route
| Conditions | Yield |
|---|---|
| at 30℃; for 16h; Pseudomonas putida ATCC 33015; | 90% |
| With potassium permanganate In water at 76 - 82℃; for 5.7h; Temperature; Industrial scale; | 81.6% |
| With sodium tungstate; oxygen; cobalt(II) nitrate; manganese(ll) chloride In water | 75.6% |
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen; sodium hydroxide In methanol at 60℃; under 15001.5 Torr; for 12h; Autoclave; Inert atmosphere; | 68% |
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen; sodium hydroxide In methanol at 60℃; under 15001.5 Torr; for 12h; Reagent/catalyst; Autoclave; Inert atmosphere; | 71% |
- 128229-06-1
2-(chloromethyl)-5-methylpyrazine hydrochloride
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With potassium carbonate In water; tert-butyl alcohol at 60℃; Ni-anode, 12 mA/cm2; | 82% |
| Multi-step reaction with 2 steps 1: 74 percent / KOAc, KHCO3 / ethanol / 6 h / Heating 2: 93 percent / 1 N aq. NaOH / 40 °C / Ni-anode, 12 mA/cm2 View Scheme | |
| Multi-step reaction with 2 steps 1: 65 percent / KOAc / ethanol / 6 h / Heating 2: 87 percent / 1 N aq.NaOH / 40 °C / Ni-anode, 12 mA/cm2 View Scheme |
- 61892-95-3
2-Hydroxymethyl-5-methylpyrazine
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 40℃; Ni-anode, 12 mA/cm2; | 93% |
| With potassium permanganate for 0.5h; Oxidation; |
- 98006-89-4
2-Acetoxymethyl-5-methylpyrazine
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 40℃; Ni-anode, 12 mA/cm2; | 87% |
| Multi-step reaction with 2 steps 1: 85 percent / NaOH / ethanol / 0.17 h 2: aq. KMnO4 / 0.5 h View Scheme |
| Conditions | Yield |
|---|---|
| at 175 - 185℃; under 2 Torr; | 71% |
- 123-32-0
2,5-dimethyl-pyrazine
A
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
B
- 122-05-4
2,5-pyrazinedicarboxylic acid
| Conditions | Yield |
|---|---|
| With chromium(III) nitrate In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode; | A 40% B 20% |
- 81831-68-7
2-methyl-5-pyrazinylmethyl chloride
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 90 percent Chromat. / ethanol / Heating 2: 85 percent / NaOH / ethanol / 0.17 h 3: aq. KMnO4 / 0.5 h View Scheme |
- 88394-05-2
3-carboxamido-2-hydroxy-6-methylpyrazine
- 5521-55-1
2-methylpyrazin-5-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sulfuric acid / 12 h / 100 °C 2: thionyl chloride / 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide / 6 h / 80 °C 3: palladium 10% on activated carbon; hydrogen; sodium hydroxide / methanol / 12 h / 60 °C / 15001.5 Torr / Autoclave; Inert atmosphere View Scheme | |
| Multi-step reaction with 3 steps 1: sulfuric acid / 12 h / 100 °C 2: dibromo sulfoxide / 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide / 6 h / 80 °C 3: palladium 10% on activated carbon; hydrogen; sodium hydroxide / methanol / 12 h / 60 °C / 15001.5 Torr / Autoclave; Inert atmosphere View Scheme |
5-Methyl-2-pyrazinecarboxylic acid Chemical Properties
Molecular Structure of 5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1):
IUPAC Name: 5-methylpyrazine-2-carboxylic acid
Empirical Formula: C6H6N2O2
Molecular Weight: 138.124
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 52.08 Å2
Molar Refractivity: 34.19 cm3
Molar Volume: 104.6 cm3
Index of Refraction: 1.566
Surface Tension: 63.3 dyne/cm
Density: 1.319 g/cm3
Flash Point: 145.2 °C
Enthalpy of Vaporization: 58.9 kJ/mol
Boiling Point: 316.5 °C at 760 mmHg
Vapour Pressure: 0.000172 mmHg at 25°C
Melting Point: 167-171 °C(lit.)
Synonyms of 5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1): 2-pyrazinecarboxylic acid, 5-methyl- ; 5-Methylpyrazine-2-Carboxylic Acid ; 5-Methylpyrazinecarboxylic acid ; Pyrazinecarboxylic acid, 5-methyl-
5-Methyl-2-pyrazinecarboxylic acid Uses
5-Methyl-2-Pyrazinecarboxylic acid (CAS NO.5521-55-1) is used as an intermediate in the synthesis of glipizide.
5-Methyl-2-pyrazinecarboxylic acid Safety Profile
Hazard Codes: :
Xi
Risk Statements: 41-36/37/38
R41:Risk of serious damage to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39:Wear eye / face protection.
S36:Wear suitable protective clothing.
WGK Germany: 1
Hazard Note: Irritant
5-Methyl-2-pyrazinecarboxylic acid Specification
5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1) is a pale brown powder, it can be made by 2,5-2-methyl or 2-methyl-5-(substituted) methyl pyrazine electrolytic oxidation .Preparation Products are Acipimox , raw material is 2-Methylpyrazine .
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