Basic information
- Name:
5-Methyl-2-pyrazinecarboxylic acid
- CAS No.:
5521-55-1
- Molecular Structure:

- Formula:
- C6H6N2O2
- Molecular Weight:
- 138.13 .
- Synonyms:
- 2-Pyrazinecarboxylicacid, 5-methyl-;Pyrazinecarboxylic acid, 5-methyl- (7CI,8CI,9CI);2-Methylpyrazine-5-carboxylic acid;5-Methyl-2-pyrazinoic acid;5-Methylpyrazine carboxylic acid;5-Methylpyrazine-2-Carboxylic Acid;
- EINECS:
- 413-260-9
- Density:
- 1.319 g/cm3
- Melting Point:
- 167-171 °C(lit.)
- Boiling Point:
- 316.5 °C at 760 mmHg
- Flash Point:
- 145.2 °C
- Appearance:
- Pale Brown Powder
- Hazard Symbols:
Xi- Risk Codes:
- 41-36/37/38
- Safety Description:
- 26-39-36 Details
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Chemistry
Molecular Structure of 5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1):

IUPAC Name: 5-methylpyrazine-2-carboxylic acid
Empirical Formula: C6H6N2O2
Molecular Weight: 138.124
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 52.08 Å2
Molar Refractivity: 34.19 cm3
Molar Volume: 104.6 cm3
Index of Refraction: 1.566
Surface Tension: 63.3 dyne/cm
Density: 1.319 g/cm3
Flash Point: 145.2 °C
Enthalpy of Vaporization: 58.9 kJ/mol
Boiling Point: 316.5 °C at 760 mmHg
Vapour Pressure: 0.000172 mmHg at 25°C
Melting Point: 167-171 °C(lit.)
Synonyms of 5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1): 2-pyrazinecarboxylic acid, 5-methyl- ; 5-Methylpyrazine-2-Carboxylic Acid ; 5-Methylpyrazinecarboxylic acid ; Pyrazinecarboxylic acid, 5-methyl-
Uses
5-Methyl-2-Pyrazinecarboxylic acid (CAS NO.5521-55-1) is used as an intermediate in the synthesis of glipizide.
Safety Profile
Hazard Codes: :
Xi
Risk Statements: 41-36/37/38
R41:Risk of serious damage to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39:Wear eye / face protection.
S36:Wear suitable protective clothing.
WGK Germany: 1
Hazard Note: Irritant
Specification
5-Methyl-2-pyrazinecarboxylic acid (CAS NO.5521-55-1) is a pale brown powder, it can be made by 2,5-2-methyl or 2-methyl-5-(substituted) methyl pyrazine electrolytic oxidation .Preparation Products are Acipimox , raw material is 2-Methylpyrazine .

