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Name	6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone	EINECS	605-867-4
CAS No.	179688-29-0	Density	1.26 g/cm³
PSA	82.67000	LogP	0.97350
Solubility	N/A	Melting Point	185-189 °C
Formula	C₁₄H₁₈N₂O₅	Boiling Point	467.8 °C at 760 mmHg
Molecular Weight	294.307	Flash Point	236.7 °C
Transport Information	N/A	Appearance	off-white solid
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	6,7-bis-(2-Methoxyethoxy)quinazolin-4(3h)-one;4(1H)-Quinazolinone,6,7-bis(2-methoxyethoxy)- (9CI);6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one;6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one;6,7-Di(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one;4(3H)-Quinazolinone,6,7-bis(2-methoxyethoxy)-;	Article Data	47

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Synthetic route

: C14H17NO6

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With ammonium hydroxide; tetrabutylammomium bromide for 0.0833333h; Time; Irradiation;	99.2%
With ammonium hydroxide; tetrabutylammomium bromide In dichloromethane at 20℃; Reagent/catalyst;	99.2%
With ammonium hydroxide; tetrabutylammomium bromide for 0.0833333h; Time; Sonication;	99.2%
With ammonium hydroxide; tetrabutyl ammonium fluoride at 20℃; for 0.25h; Time; Sonication;	99.2%

: 3473-63-0
formamidine acetic acid

: 179688-27-8
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
Stage #1: formamidine acetic acid; ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate In butan-1-ol at 80℃; for 5h; Inert atmosphere; Stage #2: In Isopropyl acetate for 1h; Reflux;	98%
In ethanol at 55℃; for 3h; Concentration; Temperature; Solvent; Green chemistry;	98.5%
In 2-methoxy-ethanol at 125℃; for 8h;	63.5%

: 1208902-93-5
6,7-di(2'-methoxyethoxy)quinazoline

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With peracetic acid; sulfuric acid In ethanol at 60℃; for 4h;	93%
Stage #1: 6,7-di(2'-methoxyethoxy)quinazoline With ammonium cerium (IV) nitrate; acetic acid In water Stage #2: With sodium hydroxide In water	88%

: 107-31-3
Methyl formate

: 476168-17-9
2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With ammonia In methanol for 7h; Concentration; Reflux;	92%

: 50-00-0
formaldehyd

: 236750-62-2
2-amino-4,5-bis(2-methoxyethyloxy)benzamide

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
In water at 130℃; for 24h; Temperature;	92%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 236750-62-2
2-amino-4,5-bis(2-methoxyethyloxy)benzamide

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile at 70℃;	92%

: 179688-27-8
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With ammonium formate In N,N-dimethyl-formamide at 160℃;	79%

: 2-((6,7-bis(2-methoxyethoxy))-4-quinazolinylamino)-ethanol

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With hydrogenchloride In water at 100 - 105℃; for 2h;	71%
With hydrogenchloride In water at 100 - 105℃; for 2h;

: 16712-16-6, 64165-14-6, 65387-22-6, 70179-79-2, 540-69-2
ammonium formate

: 179688-27-8
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
In formamide at 160℃; for 3h;	62%

: 1006377-63-4
C13H19NO5

: 179688-29-0
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic anhydride / 110 °C 2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Chemical Properties

Molecular Formula: C₁₄H₁₈N₂O₅
Molecular Weight: 294.30 g/mol
Product Categories: intermidiate of Erlotinib hydrochloride; Erlotinib;Aromatics Compounds; Intermediate of erlotinib hydrochloride; Aromatics; Heterocycles; Intermediates
Index of Refraction: 1.552
Molar Refractivity: 74.11 cm³
Molar Volume: 231.9 cm³
Polarizability: 29.38×10^-24 cm³
Surface Tension: 42.4 dyne/cm
Density: 1.26 g/cm³
Flash Point: 236.7 °C
Enthalpy of Vaporization: 72.99 kJ/mol
Boiling Point: 467.8 °C at 760 mmHg
Melting Point: 185-189 °C
Vapour Pressure of 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone (CAS NO.179688-29-0): 6.3E-09 mmHg at 25 °C

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Uses

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone (CAS NO.179688-29-0) is used as an intermediate in the synthesis of erlotini.

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Specification

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone (CAS NO.179688-29-0), its Synonyms are 6,7-Bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one ; 6,7-Bis-(2-methoxyethoxy)quinazolin-4(3H)-one ; 6,7-Bis(2-methoxyethoxy)-quinazolin-4-one . It is off-white solid.

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