6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (2328-12-3),6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (2328-12-3) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:
2328-12-3
Molecular Structure:
Formula:
C₁₁H₁₆ClNO₂
Molecular Weight:
229.7032
Synonyms:
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (7CI,8CI,9CI);1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinolinehydrochloride;6,7-Bis(methyloxy)-1,2,3,4-tetrahydroisoquinoline hydrochloride;Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1);6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride;6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinehydrochloride;Heliamine hydrochloride;
EINECS:
251-223-7
Density:
1.071g/cm³
Melting Point:
260-265 °C(lit.)
Boiling Point:
314.9 °C at 760 mmHg
Flash Point:
124.7 °C
Appearance:
white to slightly beige shiny flakes
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-36 Details

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Chemistry

Molecule structure of 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS NO.2328-12-3):

IUPAC Name: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Molecular Weight: 229.70324 g/mol
Molecular Formula: C₁₁H₁₆ClNO₂
Melting Point: 260-265 °C(lit.)
Flash Point: 124.7 °C
Enthalpy of Vaporization: 55.61 kJ/mol
Boiling Point: 314.9 °C at 760 mmHg
Vapour Pressure: 0.000451 mmHg at 25 °C
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Exact Mass: 229.086956
MonoIsotopic Mass: 229.086956
Topological Polar Surface Area: 30.5
Heavy Atom Count: 15
Canonical SMILES: COC1=C(C=C2CNCCC2=C1)OC.Cl
InChI: InChI=1S/C11H15NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-6,12H,3-4,7H2,1-2H3;1H
InChIKey: SHOWAGCIRTUYNA-UHFFFAOYSA-N
EINECS: 251-223-7
Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Isoquinolines

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	272mg/kg (272mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968.
mouse	LDLo	parenteral	160mg/kg (160mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 165, 1938.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: NX5017980
Hazard Note: Irritant

Specification

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS NO.2328-12-3) is also named as 1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride ; Heliamine hydrochloride ; Isoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydro-, hydrochloride ; NSC 18443 . 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS NO.2328-12-3) is white to slightly beige shiny flakes.