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Name |
6-Hydroxydopamine |
EINECS | N/A |
CAS No. | 1199-18-4 | Density | 1.395g/cm3 |
PSA | 86.71000 | LogP | 1.00490 |
Solubility | N/A | Melting Point |
N/A |
Formula | C8H11 N O3 | Boiling Point | 406°Cat760mmHg |
Molecular Weight | 169.18 | Flash Point | 199.3°C |
Transport Information | N/A | Appearance | N/A |
Safety | Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
2,4,5-Trihydroxyphenethylamine;5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-Hydroxydopamine; Dopamine, 6-hydroxy-;Oxidopamine; Topamine |
Article Data | 12 |
IUPAC Name: 5-(2-Aminoethyl)benzene-1,2,4-triol
Synonyms of 6-Hydroxydopamine (CAS NO.1199-18-4): 2,4,5-Trihydroxyphenethylamine ; 5-(2-Aminoethyl)-1,2,4-benzenetriol ; Hydroxydopamine ; Oxidopamina ; Oxidopaminum ; 1,2,4-Benzenetriol, 5-(2-aminoethyl)-
CAS NO: 1199-18-4
Molecular Formula: C16H19NaO2
Molecular Weight : 266.3106
Molecular Structure:
H bond acceptors: 4
H bond donors: 5
Freely Rotating Bonds: 6
Polar Surface Area: 30.93 Å2
Index of Refraction: 1.664
Molar Refractivity: 44.98 cm3
Molar Volume: 121.2 cm3
Surface Tension: 76 dyne/cm
Density: 1.395 g/cm3
Flash Point: 199.3 °C
Enthalpy of Vaporization: 68.33 kJ/mol
Boiling Point: 406 °C at 760 mmHg
Vapour Pressure: 3.58E-07 mmHg at 25°C
EINECS: 214-842-3
Form: 6-Hydroxydopamine (CAS NO.1199-18-4) is solid.
6-Hydroxydopamine (CAS NO.1199-18-4) is a neurotoxin used by scientists to selectively kill dopaminergic and noradrenergic neurons.The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines for treating Parkinson's disease in humans. It is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively kill dopaminergic neurons only.
1. | mmo-sat 100 µg/plate ABCHA6 45,327,81 | |
2. | mma-sat 100 µg/plate ABCHA6 45,327,81 |
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
1.Reactivity Profile: Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
2.Health Hazard :SYMPTOMS: Symptoms of exposure to oxidopamine may include a prolonged decomposition in catecholamine content of the heart (shown to be due to the destruction of sympathetic nerve endings).