6-Methyleneandrosta-1,4-diene-3,17-dione

IUPAC Name: (8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Synonyms of 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4): Exemestane [USAN:INN:BAN] ; Androsta-1,4-diene-3,17-dione, 6-methylene- ; Aromasin ; Exemestane ; Exemestano ; Exemestano [INN-Spanish] ; Exemestanum ; Exemestanum [INN-Latin] ; Fce 24304 ; HSDB 7463 ; UNII-NY22HMQ4BX
CAS NO: 107868-30-4
Classification Code: Antineoplastic ; Antineoplastic agents ; Antineoplastic used to treat advanced breast ;cancer [aromatase inhibitor] ; Aromatase Inhibitors ; Enzyme inhibitors
Molecular Formula: C₂₀H₂₄O₂
Molecular Weight: 296.4034
Molecular Structure:
Melting Point: 155.13°C 
Polar Surface Area: 34.14 Å²
Index of Refraction: 1.572
Molar Refractivity: 85.79 cm³
Molar Volume: 260.5 cm³
Surface Tension: 42.9 dyne/cm
Density: 1.13 g/cm³
Flash Point: 169 °C
Enthalpy of Vaporization: 71.32 kJ/mol
Boiling Point: 453.7 °C at 760 mmHg
Vapour Pressure: 2.02E-08 mmHg at 25°C

 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4) can be used as an antineoplastic (hormonal) .An oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal women.
 

The production of 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4) Androst -4 - ene -3,17 - dione and triethyl orthoformate and ethanol are dissolved in tetrahydrofuran.In the presence of p-toluenesulfonic acid reaction,add N-methyl aniline and formaldehyde solution to continue to respond. The Mannich reaction products are soluble in benzoic acid and anhydrous 2 chew alkyl.Under the action of the DDQ,exemestane can be received, with a total yield of 45%.

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information of 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4).
Hazard Symbols: A reproductive hazard.
Hazardous Substances Data 107868-30-4(Hazardous Substances Data)
 

Hazards Identification of 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4).
Inhalation:Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
Skin:Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
Eyes:Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
Ingestion:If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
Stability and Reactivity of 6-Methyleneandrosta-1,4-diene-3,17-dione (CAS NO.107868-30-4): Combustion Products:Emits toxic fumes under fire conditions.