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Acebutolol

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Acebutolol

EINECS 253-539-0
CAS No. 37517-30-9 Density 1.118 g/cm3
Solubility 259 mg/L in water Melting Point 119-123 °C
Formula C18H28N2O4 Boiling Point 564.1 °C at 760 mmHg
Molecular Weight 336.48 Flash Point 295 °C
Transport Information Appearance Crystalline solid
Safety Risk Codes
Molecular Structure Molecular Structure of 37517-30-9 (Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-) Hazard Symbols
Synonyms

(+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;(RS)-Acebutolol;Monitan;dl-Acebutolol;

 

Acebutolol Chemical Properties

Empirical Formula: C18H28N2O4
Molecular Weight: 336.4259 
EINECS: 253-539-0
Index of Refraction: 1.542
Density: 1.118 g/cm3
Flash Point: 295 °C
Enthalpy of Vaporization: 89.18 kJ/mol
Boiling Point: 564.1 °C at 760 mmHg
Vapour Pressure: 1.45E-13 mmHg at 25 °C
Melting point: 119-123 °C
Water solubility: 259 mg/L
Appearance: Crystalline Solid
Product categories: Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor
Structure of Acebutolol (CAS NO.37517-30-9):
         

Acebutolol Uses

 Acebutolol (CAS NO.37517-30-9) has been used of cardiovascular β-blocker.

Acebutolol Production

 Acebutolol (CAS NO.37517-30-9) has been obtained from the reaction of 5'-Butylamido -2 '- (2,3 - epoxy propoxy) acetophenone and Isopropylamine .

Acebutolol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 4mg/kg (4mg/kg) CARDIAC: CHANGE IN RATE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
KIDNEY, URETER, AND BLADDER: CHANGES IN BLOOD VESSELS OR IN CIRCULATION OF KIDNEY
Masui to Sosei. Anesthesia and Resuscitation. Vol. 16, Pg. 13, 1980.
man TDLo oral 137mg/kg/24D- (137mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Annals of Internal Medicine. Vol. 111, Pg. 533, 1989.
mouse LD50 intravenous 75200ug/kg (75.2mg/kg)   Nouvelle Presse Medicale. Vol. 7, Pg. 3258, 1978.
mouse LD50 subcutaneous 125mg/kg (125mg/kg)   Cesko-Slovenska Farmacie. Vol. 42, Pg. 82, 1993.
women TDLo oral 109mg/kg/22D- (109mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Annals of Internal Medicine. Vol. 111, Pg. 533, 1989.
women TDLo oral 152mg/kg (152mg/kg) CARDIAC: CHANGE IN CONDUCTION VELOCITY
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 69, 1983.

Acebutolol Safety Profile

Moderately toxic by intravenous route. Human systemic effects by ingestion: developmental abnormalities of the cardiovascular and respiratory systems; effects on newborn in biochemical and metabolic abnormalities and reduced growth statistics. A human teratogen. When heated to decomposition it emits toxic fumes of NOx. A beta-adrenergic blocker.

Acebutolol Specification

 Acebutolol ,its cas register number is 37517-30-9. It also can be called Prent ; Acetobutolol ; Neptal and Sectral . It is a beta blocker for the treatment of hypertension and arrhythmias. Acebutolol (CAS NO.37517-30-9) is a cardioselective beta blocker with ISA, and if a patient with Asthma bronchiale or chronic obstructive pulmonary disease (COPD) needs treatment with a beta blocker, it is therefore more suitable than non cardioselective beta blockers. It has no negative impact on serum lipids and works in hypertensive patients with high, normal, or low renin plasma concentrations, although acebutolol may be more efficient in patients with high or normal renin plasma concentrations. It is well absorbed from the GI tract and undergoes extensive hepatic metabolization resulting in the desbutyl amine acetolol which is readily converted into diacetolol. Altogether, 5 to 6% of all patients treated have to discontinue Acebutolol (CAS NO.37517-30-9) due to intolerable side effects.

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