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Acrylyl chloride

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Name

Acrylyl chloride

EINECS 212-399-0
CAS No. 814-68-6 Density 1.108 g/cm3
PSA 17.07000 LogP 0.93780
Solubility Miscible with chloroform, decomposed in water and ethanol Melting Point 72-76 °C
Formula C3H3ClO Boiling Point 75.5 °C at 760 mmHg
Molecular Weight 90.5092 Flash Point 16.1 °C
Transport Information UN 3383 6.1/PG 1 Appearance Colorless liquid
Safety 16-26-28-36/37/39-45-7/9 Risk Codes 11-14-26-34
Molecular Structure Molecular Structure of 814-68-6 (Acrylyl chloride) Hazard Symbols FlammableF,VeryT+
Synonyms

Prop-2-enoyl chloride;2-Propenoyl chloride;HSDB 6330;Acrylic acid chloride;Propenoyl chloride;Acryloyl chloride;Chlorid kyseliny akrylove [Czech];NSC 93770;Acryloyl Acid;

Article Data 121

Acrylyl chloride Synthetic route

79-10-7

acrylic acid

814-68-6

acryloyl chloride

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Reagent/catalyst; Temperature;100%
With thionyl chloride98%
With oxalyl dichloride; N,N-dimethyl-formamide at 20 - 40℃; for 0.166667h; Product distribution / selectivity;96.2%
79-10-7

acrylic acid

A

814-68-6

acryloyl chloride

B

625-36-5

2-chloropropionyl chloride

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide at 80℃; under 2068.65 Torr; for 0.416667h; Reagent/catalyst; Pressure;A 4%
B 94%
With trichlorophosphate In N,N-dimethyl-formamide at 80℃; for 0.00833333h; Reagent/catalyst; Temperature;A 91%
B 6%
With thionyl chloride; N,N-dimethyl-formamide In neat (no solvent) at 60℃; for 0.0166667h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Flow reactor;
15486-96-1

3-Bromopropionyl chloride

814-68-6

acryloyl chloride

Conditions
ConditionsYield
With P(MeNCH2CH2)3N In acetonitrile at 25℃; for 0.0833333h;90%
109-92-2

ethyl vinyl ether

814-68-6

acryloyl chloride

Conditions
ConditionsYield
Stage #1: ethyl vinyl ether With oxalyl dichloride at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: at 120℃; for 0.5h; Inert atmosphere;
89%
79-10-7

acrylic acid

A

C6H7ClO3

B

814-68-6

acryloyl chloride

C

625-36-5

2-chloropropionyl chloride

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide at 60℃; for 0.0166667h; Reagent/catalyst;A 7%
B 82%
C 11%
75-44-5

phosgene

79-10-7

acrylic acid

814-68-6

acryloyl chloride

Conditions
ConditionsYield
64%
7446-81-3

sodium 2-propenoate

814-68-6

acryloyl chloride

Conditions
ConditionsYield
With trichlorophosphate
98-88-4

benzoyl chloride

79-10-7

acrylic acid

814-68-6

acryloyl chloride

625-36-5

2-chloropropionyl chloride

814-68-6

acryloyl chloride

Conditions
ConditionsYield
With barium(II) chloride at 180℃;
With fired clay fragments at 140 - 170℃;
With tripentylamine at 80 - 140℃;
With fired clay fragments at 140 - 170℃;
With barium(II) chloride at 180℃;
107-02-8

acrolein

814-68-6

acryloyl chloride

Conditions
ConditionsYield
With chlorine at 285 - 320℃;

Acrylyl chloride Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Acrylyl chloride Specification

The Acryloyl chloride with CAS registry number of 814-68-6 is also known as 2-Propenoyl chloride. The IUPAC name is Prop-2-enoyl chloride. It belongs to product categories of Industrial/Fine Chemicals; Halogen Compounds; Acid Chlorides. Its EINECS registry number is 212-399-0. In addition, the formula is C3H3ClO and the molecular weight is 90.51. This chemical is a colorless liquid and should be stored in sealed containers in cool, dry place with protection of inert gas.

Physical properties about Acryloyl chloride are: (1)ACD/LogP: 1.06; (2)ACD/LogD (pH 5.5): 1.06; (3)ACD/LogD (pH 7.4): 1.06; (4)ACD/BCF (pH 5.5): 3.74; (5)ACD/BCF (pH 7.4): 3.74; (6)ACD/KOC (pH 5.5): 89.45; (7)ACD/KOC (pH 7.4): 89.45; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.417; (11)Molar Refractivity: 20.55 cm3; (12)Molar Volume: 81.6 cm3; (13)Surface Tension: 25.7 dyne/cm; (14)Density: 1.108 g/cm3; (15)Flash Point: 16.1 °C; (16)Enthalpy of Vaporization: 31.66 kJ/mol; (17)Boiling Point: 75.5 °C at 760 mmHg; (18)Vapour Pressure: 105 mmHg at 25 °C.

Preparation of Acryloyl chloride: it is prepared by reaction of acrylic acid with phosphorus trichloride with molar ratio of 1:0.333. Firstly, the reaction mixture is heated to boiling. Secondly, the mixture is cooled to 60-70 °C for 15 minutes, then cooled to room temperature for 2 hours. At last, separate the upper product and add cuprous chloride for vacuum distillation. Product is obtained by collecting fraction at 30-32 °C. The yield is about 66%.

Uses of Acryloyl chloride: it is mainly used for synthesis of acrylic esters, acrylamide compounds and also used as intermediate for preparing anti-fog agent. For example, it is used to produce 1-acryloyl-pyrrolidine by reaction with pyrrolidine. The reaction needs reagent Et3N and solvent CH2Cl2 at 0 °C for 2.5 hours. The yield is about 67%.

Acryloyl chloride is used to produce 1-acryloyl-pyrrolidine by reaction with pyrrolidine.

When you are using this chemical, please be cautious about it. As a chemical, it is highly flammable that may cause burns. It reacts violently with water and will be toxic if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection. Keep container tightly closed and in a well-ventilated place away from sources of ignition. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If accident happens or you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C=CC(=O)Cl
2. InChI: InChI=1S/C3H3ClO/c1-2-3(4)5/h2H,1H2
3. InChIKey: HFBMWMNUJJDEQZ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC50 inhalation 92mg/m3/2H (92mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 17, 1982.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03367,
rat LCLo inhalation 25ppm/4H (25ppm) SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA
British Journal of Industrial Medicine. Vol. 27, Pg. 1, 1970.

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