NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

The IUPAC name of Adriamycin is (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione. With the CAS registry number 23214-92-8 and EINECS 245-495-6, it is also named as Doxorubicin. The classification codes are Antibiotics, Antineoplastic; Antineoplastic; Antineoplastic agents; Drug / Therapeutic Agent; Human Data; Mutation data; Natural Product; Reproductive Effect; Skin / Eye Irritant; Tumor data. It is highly toxic and flammable. When heated to decomposition it emits very toxic fumes of NO_x and HCl. So the storage environment should be well-ventilated, low-temperature and dry. Keep Adriamycin separate from raw materials of food. What's more, this drug is photosensitive, and containers are often covered by an aluminum bag and/or brown wax paper to prevent light from affecting it.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.24; (2)# of Rule of 5 Violations: 3; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 12; (8)#H bond donors: 7; (9)#Freely Rotating Bonds: 11; (10)Polar Surface Area: 206.07 Å²; (11)Index of Refraction: 1.71; (12)Molar Refractivity: 131.521 cm³; (13)Molar Volume: 336.639 cm³; (14)Surface Tension: 96.438 dyne/cm; (15)Enthalpy of Vaporization: 123.508 kJ/mol; (16)Vapour Pressure: 0 mmHg at 25°C; (17)Rotatable Bond Count: 5; (18)Tautomer Count: 81; (19)Exact Mass: 543.174061; (20)MonoIsotopic Mass: 543.174061; (21)Topological Polar Surface Area: 206; (22)Heavy Atom Count: 39; (23)Complexity: 977.

Preparation and Uses of Adriamycin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas. The most serious adverse effect of this drug is life-threatening heart damage. In addition, this chemical can react with formaldehyde to get doxoform. This reaction needs reagent Et₃N*AcOH and AcOH at temperature of 25 °C. The reaction time is 15 hours. The yield is 70%.

People can use the following data to convert to the molecule structure. 
1. SMILES:C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O
2. InChI:InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
3. InChIKey:AOJJSUZBOXZQNB-TZSSRYMLBG

The following are the toxicity data which has been tested.