Basic information
- Name:
Ambroxol hydrochloride
- CAS No.:
23828-92-4
- Molecular Structure:
- Formula:
- C13H19Br2ClN2O
- Molecular Weight:
- 414.57
- Deleted CAS:
- 15942-05-9
- Synonyms:
- Hustless (TN);trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride;(2-amino-3,5-dibromo-phenyl)methyl-(4-hydroxycyclohexyl)azanium;18683-91-5;Ambroxol lozenge;Ambroxol Hcl;Altretamine;Mucoangin;Hustless;Mucolear;
- EINECS:
- 245-899-2
- Melting Point:
- 233-234.5 °C
- Boiling Point:
- 468.6 °C at 760 mmHg
- Flash Point:
- 237.2 °C
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xn- Risk Codes:
- 22
- Safety Description:
- 36 Details
- particular:
- particular
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Chemistry
Molecular Structure:
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Molecular Formula: C13H19Br2ClN2O
Molecular Weight: 414.5638
IUPAC Name: 4-[(2-Amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol hydrochloride
Synonyms of Ambroxol hydrochloride (CAS NO.23828-92-4): Ambroxol lozenge ; CCRIS 8686 ; EINECS 245-899-2 ; Mucoangin ; Mucolear ; Mucosolvan ; NA 872 hydrochloride ; UNII-CC995ZMV90 ; trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride ; Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, monohydrochloride, trans- (9CI) ; Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, hydrochloride, trans- (8CI) ; Cyclohexanol, 4-(N-(2-amino-3,5-dibromobenzyl)amino)-, hydrochloride (E)-
CAS NO: 23828-92-4
Classification Code: Drug / Therapeutic Agent ; Reproductive Effect
Melting Point: 233-234.5°C
H bond acceptors: 3
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 58.28 Å2
Flash Point: 251.7 °C
Enthalpy of Vaporization: 79.99 kJ/mol
Boiling Point: 492.6 °C at 760 mmHg
Vapour Pressure: 1.61E-10 mmHg at 25°C
Uses
Ambroxol hydrochloride (CAS NO.23828-92-4) is used as antitussive and expectorant agent.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| dog | LD50 | oral | 500mg/kg (500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| guinea pig | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| guinea pig | LD50 | oral | 1180mg/kg (1180mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| mouse | LD50 | intraperitoneal | 268mg/kg (268mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| mouse | LD50 | intravenous | 138mg/kg (138mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| mouse | LD50 | oral | 2380mg/kg (2380mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981. |
| mouse | LD50 | subcutaneous | 1060mg/kg (1060mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981. |
| rabbit | LD50 | intravenous | 64mg/kg (64mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981. |
| rabbit | LD50 | oral | 2597mg/kg (2597mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981. |
| rabbit | LDLo | intraperitoneal | 400mg/kg (400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978. | |
| rat | LD50 | intraperitoneal | 262mg/kg (262mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: PERITONITIS | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981. |
| rat | LD50 | intravenous | 100mg/kg (100mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981. |
| rat | LD50 | oral | 4203mg/kg (4203mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981. |
| rat | LD50 | subcutaneous | 1489mg/kg (1489mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981. |
Safety Profile
Safety Information of Ambroxol hydrochloride (CAS NO.23828-92-4):
Hazard Codes:Xn 
Risk Statements:22
22:Harmful if swallowed
Safety Statements:36
36:Wear suitable protective clothing
WGK Germany:3
RTECS:GV8423000
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Br−, NOx, and HCl.
