Basic information
- Name:
Aminopyrine sodium sulfonate
- Superlist Name:
- Dipyrone
- CAS No.:
68-89-3
- Molecular Structure:
- Formula:
- C13H16N3NaO4S
- Molecular Weight:
- 334.38
- Deleted CAS:
- 57904-20-8
- Synonyms:
- Dipyrone(6CI);Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt (8CI);ARPF;Optalgin;Pyralgine;Pyretin;Sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate;Sodium noramidopyrine methanesulfonate;Sulpin;Sulpyrine;Algopyrin;Anador;Analgin;Andolor;Conmel;Diprofarn;Metamizol;Metamizole sodium;Metamizole sodium salt;Methamizole sodium;Metilon;Neo-melubrine;Noramidopyrine methanesulfonatesodium;Noraminophenazone sodium mesylate;Novalgetol;Novamidazophen;Novaminsulfone;Novaminsulfonium;Noveltex;
- EINECS:
- 200-694-7
- Solubility:
- easily soluble in water, little soluble in alcohol
- Appearance:
- solid
- Hazard Symbols:
Xn- Risk Codes:
- 42/43
- Safety Description:
- 36 Details
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Chemistry
IUPAC Name: Sodium [(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate
Synonyms of Aminopyrine sodium sulfonate (CAS NO.68-89-3): Dipyrone ; Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt ; Methanesulfonic acid, (antipyrinylmethylamino)-, monosodium salt ; Sodium ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)methanesulphonate
CAS NO: 68-89-3
Classification Code: Analgesics ; Analgesics, Non-Narcotic ; Anti-Inflammatory Agents ; Anti-inflammatory agents, non-steroidal ; Antirheumatic Agents ; Drug / Therapeutic Agent ; Human Data ; Mutation data ; Peripheral Nervous System Agents ; Reproductive Effect ; Sensory System Agents ; Tumor data
Molecular Formula: C13H16N3NaO4S
Molecular Weight: 333.3386
Molecular Structure:
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Polar Surface Area: 89.54 Å2
Product Categories: PHARMACEUTICALS ; DIO - DIZForensic and Veterinary Standards ; Alphabetic ; D ; Drugs&Metabolites ; Neat Compounds ; Cosmetic Ingredients & Chemicals
Uses
Aminopyrine sodium sulfonate (CAS NO.68-89-3), with detoxification, analgesic, anti-rheumatic effect, is mainly used for cooling, also used for acute arthritis, rheumatic pain, muscle pain, headache and so on.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
| mouse | LC50 | inhalation | 37200mg/m3 (37200mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(10), Pg. 36, 1969. | |
| mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 107, Pg. 322, 1956. | |
| mouse | LD50 | intravenous | 2197mg/kg (2197mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. | |
| mouse | LD50 | oral | 2891mg/kg (2891mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. | |
| mouse | LD50 | subcutaneous | 69mg/kg (69mg/kg) | Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. | |
| mouse | LD50 | unreported | 2750mg/kg (2750mg/kg) | Journal of Drug Research. Vol. 4, Pg. 89, 1972. | |
| rabbit | LD50 | oral | 2150mg/kg (2150mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979. |
| rabbit | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
| rat | LC | inhalation | > 900mg/m3 (900mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979. | |
| rat | LD50 | intramuscular | 1625mg/kg (1625mg/kg) | Russian Pharmacology and Toxicology Vol. 51, Pg. 183, 1988. | |
| rat | LD50 | intraperitoneal | 2470mg/kg (2470mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 478, 1977. |
| rat | LD50 | intravenous | 2182mg/kg (2182mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 703, 1976. | |
| rat | LD50 | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. |
| rat | LD50 | subcutaneous | 2117mg/kg (2117mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. |
Safety Profile
Hazard Codes of Aminopyrine sodium sulfonate (CAS NO.68-89-3): 
Xn
Risk Statements: 42/43
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 36
S36: Wear suitable protective clothing.
WGK Germany: 2
RTECS: PB1300000
Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.
