Basic information
- Name:
Amlexanox
- CAS No.:
68302-57-8
- Molecular Structure:
- Formula:
- C16H14N2O4
- Molecular Weight:
- 298.30
- Synonyms:
- 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid;5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-;Aphtheal;Elics;Solfa;
- Density:
- 1.408 g/cm3
- Melting Point:
- >300 °C
- Boiling Point:
- 570 °C at 760 mmHg
- Flash Point:
- 298.5 °C
- Appearance:
- white crystalline solid
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Chemistry
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IUPAC Name: 2-Amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
Molecular Formula: C16H14N2O4
Molecular Weight: 298.29 g/mol
Mol File: 68302-57-8.mol
InChI: InChI=1/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
Mol File: c12c(oc3ccc(cc3c1=O)C(C)C)nc(N)c(c2)C(O)=O
Classification Code: Anti-allergic; Anti-allergic agents; Drug / Therapeutic Agent
Product Categories: Antiallergic; Antiasthmatic; Intermediates & Fine Chemicals; Pharmaceuticals
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 6
Rotatable Bond Count: 2
Tautomer Count: 6
Exact Mass: 298.095357
MonoIsotopic Mass: 298.095357
Topological Polar Surface Area: 103
Heavy Atom Count: 22
Complexity: 467
Index of Refraction: 1.668
Molar Refractivity: 78.97 cm3
Molar Volume: 211.7 cm3
Polarizability: 31.3×10-24 cm3
Density: 1.408 g/cm3
Surface Tension: 69 dyne/cm
Flash Point: 298.5 °C
Enthalpy of Vaporization: 89.95 kJ/mol
Boiling Point: 570 °C at 760 mmHg
Melting Point: >3000 °C
Vapour Pressure of Amlexanox (CAS NO.68302-57-8): 7.86E-14 mmHg at 25 °C
Uses
Amlexanox (CAS NO.68302-57-8) is used to inhibit release of allergic mediators from mast cells. It can antiallergic and antiasthmatic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 450mg/kg (450mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
| mouse | LD50 | oral | 2320mg/kg (2320mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
| mouse | LD50 | subcutaneous | 3310mg/kg (3310mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
| rat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
| rat | LD50 | oral | 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
| rat | LD50 | subcutaneous | 1400mg/kg (1400mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
Specification
Amlexanox (CAS NO.68302-57-8), its Synonyms are 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid ; 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo- ; Amlexanoxo ; Amlexanoxum ; Amoxanox ; Aphthasol . It is white crystalline solid.
