Amlodipine besylate (111470-99-6),Amlodipine besylate (111470-99-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Amlodipine besylate
CAS No.:
111470-99-6
Molecular Structure:
Formula:
C₂₀H₂₅ClN₂O₅^.C₆H₆O₃S
Molecular Weight:
567.05
Synonyms:
Amlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3,5-Pyridinedicarboxylic acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester,monobenzenesulfonate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate;Myodura;Amcard;Tensivask;Norvasc (TN);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Norvasc;Cordarene;Cardiorex;
Density:
1.227 g/cm³
Melting Point:
199-201 ºC
Boiling Point:
527.2 ºC at 760 mmHg
Flash Point:
272.6 ºC
Solubility:
Slightly soluble in water; sparingly soluble in ethanol
Appearance:
White powder
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38-20/21/22
Safety Description:
26-36 Details

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Chemistry

IUPAC Name: Benzenesulfonic acid; 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Formula: C₂₀H₂₅ClN₂O₅^.C₆H₆O₃S
Molecular Weight: 567.05 g/mol
Canonical SMILES: C=1([C@@H](C(=C(NC1COCCN)C)C(OC)=O)c1c(cccc1)Cl)C(OCC)=O.c1ccccc1S(O)(=O)=O
InChI: InChI=1/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
Product Categories: Active Pharmaceutical Ingredients; Dihydropyridine Class Chemicals; Intermediates & Fine Chemicals; Pharmaceuticals; Amlodipine
Classification Code: Anti-anginal; Antihypertensive; Drug / Therapeutic Agent; Human Data; Reproductive Effect
Melting Point: 199-201 °C
solubility: DMSO: 20 mg/mL
Flash Point: 272.6 °C
Enthalpy of Vaporization: 80.17 kJ/mol
Boiling Point: 527.2 °C at 760 mmHg
Vapour Pressure of Amlodipine besylate (CAS NO.111470-99-6): 3.34E-11 mmHg at 25 °C

Uses

Amlodipine besylate (CAS NO.111470-99-6) is a dihydropyridine calcium channel blocker and used as an antianginal and antihypertensive.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	10mg/kg (10mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994.
man	TDLo	oral	1429ug/kg (1.429mg/kg)	VASCULAR: SHOCK KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998.
mouse	LD50	intraperitoneal	31mg/kg (31mg/kg)		Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	oral	37mg/kg (37mg/kg)		Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	subcutaneous	36mg/kg (36mg/kg)		Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	intraperitoneal	42mg/kg (42mg/kg)		Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	oral	393mg/kg (393mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BLOOD: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991.
rat	LD50	subcutaneous	678mg/kg (678mg/kg)		Drugs in Japan Vol. -, Pg. 71, 1995.
women	TDLo	oral	1mg/kg (1mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997.
women	TDLo	unreported	6mg/kg/60D-I (6mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Lancet. Vol. 341, Pg. 1102, 1993.

Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Amlodipine besylate (CAS NO.111470-99-6): US7967700

Specification

Amlodipine besylate (CAS NO.111470-99-6), its Synonyms are -Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate ; Amcard ; Amdepin ; Amdipin ; Amlodin ; Amlodipine benzenesulfonate ; Amlodipine besilate ; ,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate ; 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate . It is white crystalline solid.