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Ammonium chloride

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Name

Ammonium chloride

EINECS 235-186-4
CAS No. 12125-02-9 Density 1.5274 g/cm3
PSA 0.00000 LogP -2.61980
Solubility in water: 297 g/L (0 °C), 372 g/L (20 °C), 773 g/L (100 °C) Melting Point 338 °C (decomposes)
Formula NH4Cl Boiling Point 40.4 °C at 760 mmHg
Molecular Weight 53.4915 Flash Point N/A
Transport Information UN 9085 Appearance white crystalline solid
Safety 2-22 Risk Codes 22-36
Molecular Structure Molecular Structure of 12125-02-9 (Ammonium chloride) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

Ammoniumchloride (8CI);Amchlor;Ammoneric;Catalyst RD;Darammon;Darvan 20;Salammoniac;Salmiac;feed grade Ammonium Chloride;food grade Ammonium Chloride;medical grade Ammonium Chloride;

Article Data 40

Ammonium chloride Synthetic route

7647-01-0

hydrogenchloride

C36H65Cr3N2Si3

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In diethyl ether96%

(η5-C5Me4SiMe3)2Ti(Cl)NH2

1333-74-0

hydrogen

12125-02-9

ammonium chloride

Conditions
ConditionsYield
With C21H24NRh(2-) In tetrahydrofuran under 3040.2 Torr; for 120h;92%
7647-01-0

hydrogenchloride

[(N(C6H3-2-PiPr2-4-CH3)2)Ti]2(μ2-NH)(μ2-N)H

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In diethyl ether; hexane at 20℃; for 1h; Inert atmosphere; Glovebox;91%
7647-01-0

hydrogenchloride

[{Ti(η5-C5Me5)}4(μ3-CH)(μ3-CH2)(μ3-N)2]

A

12129-06-5

Cp*TiCl3

B

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In diethyl ether; toluene at 60℃; for 4h; Inert atmosphere;A 86%
B 90%
7647-01-0

hydrogenchloride

7727-37-9

nitrogen

12125-02-9

ammonium chloride

Conditions
ConditionsYield
Stage #1: nitrogen With potassium graphite; [(3-methyl-2,4-bis(2,6-xylylimido)pentyl)FeCl]2; potassium chloride under 760.051 Torr;
Stage #2: hydrogenchloride
82%
With sodium t-butanolate In 1,2-dimethoxyethane; diethyl ether for 0.166667h; Schlenk technique; Sealed tube;
628-13-7

pyridine hydrochloride

[((uranium)2(N(CH3)(CH2CH2NPiPr2)2)2(rhodium)(μ-N))2]

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;82%
7647-01-0

hydrogenchloride

7664-41-7

ammonia

A

N2H7(1+)*Cl(1-)=N2H7Cl

B

ammonium chloride

C

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In gaseous matrix deposition of Ar matrix (1-2 mmol/h, 20-24 h) onto cold window; not isolated, detd. by IR spectroscopy;
7647-01-0

hydrogenchloride

7664-41-7

ammonia

A

ammonium chloride

B

12125-02-9

ammonium chloride

Conditions
ConditionsYield
In gaseous matrix deposition of N2 matrix (1-2 mmol/h, 20-24 h) onto cold window; not isolated, detd. by IR spectroscopy;
318-98-9

Inderal

A

124-38-9

carbon dioxide

B

12125-02-9

ammonium chloride

Conditions
ConditionsYield
With dihydrogen peroxide In water pH=3; Kinetics; UV-irradiation;
6569-51-3

borazine

A

10294-34-5

boron trichloride

B

12125-02-9

ammonium chloride

Conditions
ConditionsYield
With hydrogenchloride; aluminum (III) chloride In carbon disulfide at 80℃; under 30003 Torr; for 12h;

Ammonium chloride Specification

Ammonium chloride (also called Ammonium muriate) is highly soluble in water which is a white crystalline salt. It is an inorganic compound with the formula NH4Cl. Both its product name and IUPAC name are the same. The substance should be stored in cool, dry and ventilated place. What's more, it can't be mix-carried with acids and harmful toxic substances. If contact it regularly, it is likely to cause chronic inflammation in eye conjunctiva and mucous membrane in respiratory tract.

Preparation of Ammonium chloride: Ammonium chloride can also be prepared by double replacement reaction using ammonium sulfate and salt. Firstly, you should add the ammonium chloride solution into the reactor and heat by 105 °C. After that, you should add the reaction mixture into the reactor and stirred it at 117 °C. Then it is filtered and partitioned. At last, you will gain Ammonium chloride after the filtrate is treated through several processes, e.g, purification, refrigeration, filtrate and arefaction.

(NH4)2SO4 + 2 NaCl → 2 NH4Cl + Na2SO4

Ammonium chloride is the product from the reaction of hydrochloric acid and ammonia. This reaction can occur if poorly sealed bottles of household ammonia (ammonium hydroxide) and hydrochloric acid are stored in close proximity.

NH3 + HCl → NH4Cl

Uses of Ammonium chloride: Ammonium chloride is used to spice up dark sweets called salty liquorice, in baking to give cookies a very crisp texture, and in the flavouring Salmiakki Koskenkorva for vodkas. Ammonium chloride is commonly used to produce low temperatures in cooling baths. Generally, Ammonium chloride solutions with ammonia are used as buffer solutions. Ammonium chloride serves as a nitrogen source In biological applications and is used as a feed supplement in fertilizers for cattle and as an ingredient in nutritive media for yeast microbiological organisms. In fireworks and safety and contact explosives, Ammonium chloride will be used as an ingredient.

In several countries ammonium chloride is known as sal ammoniac and used as food additive. The E number for ammonium chloride used as a food additive is E510. Ammonium chloride is used in the textile and leather industry in dyeing, tanning textile printing and to luster cotton. Ammonium chloride is used as a flux in preparing metals to be tin coated, galvanized or soldered and as an expectorant in cough medicine.

Reanctions: Ammonium chloride can react with strong base to release ammonia gas. When subliming, it will involve decomposition into ammonia and hydrogen chloride gas. Meanwhile, Ammonium chloride can also react with alkali metal carbonates at elevated temperatures to give ammonia and alkali metal chloride:

NH4Cl + NaOH → NH3 + NaCl + H2O
NH4Cl → NH3 + HCl
2 NH4Cl + Na2CO3 → 2 NaCl + CO2 + H2O + 2 NH3

When you are using this chemical, please be cautious about it as the following:
Ammonium chloride may cause damage to health. It is harmful if swallowed. In addition, it is irritating to eyes, respiratory system and skin. There will be a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: [NH4+].[Cl-]
(2)InChI: InChI=1S/ClH.H3N/h1H;1H3
(3)InChIKey: NLXLAEXVIDQMFP-UHFFFAOYSA-N

Toxicity of Ammonium chloride:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 600mg/kg (600mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
domestic animals - goat/sheep LDLo oral 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
American Journal of Veterinary Research. Vol. 32, Pg. 1229, 1971.
guinea pig LDLo intravenous 220mg/kg (220mg/kg)   "Handbuch der Experimentellen Pharmakologie," Heffter, A., Berlin, Verlag von Julius Springer. V.1-3, 1920-35. For publisher information, see HEPHD2.Vol. 1, Pg. 470, 1923.
guinea pig LDLo subcutaneous 72mg/kg (72mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
infant LDLo oral 2gm/kg (2000mg/kg) CARDIAC: OTHER CHANGES American Journal of Emergency Medicine. Vol. 6, Pg. 506, 1988.
mouse LD50 intraperitoneal 485mg/kg (485mg/kg)   Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 256, Pg. 1043, 1963.
mouse LD50 intravenous 358mg/kg (358mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
Journal of Clinical Investigation. Vol. 37, Pg. 497, 1958.
mouse LD50 oral 1300mg/kg (1300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 257, 1990.
mouse LDLo subcutaneous 500mg/kg (500mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 39, 1973.
rabbit LDLo intravenous 78mg/kg (78mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit LDLo oral 1gm/kg (1000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit LDLo subcutaneous 200mg/kg (200mg/kg)   "Handbuch der Experimentellen Pharmakologie," Heffter, A., Berlin, Verlag von Julius Springer. V.1-3, 1920-35. For publisher information, see HEPHD2.Vol. 1, Pg. 470, 1923.
rat LD50 intramuscular 30mg/kg (30mg/kg)   Experimental Medicine and Surgery. Vol. 4, Pg. 223, 1946.
rat LD50 oral 1650mg/kg (1650mg/kg)   "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 15, 1972.
rat LD50 unreported 550mg/kg (550mg/kg)   French Demande Patent Document. Vol. #2444025,

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