Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Arbidol hydrochloride	EINECS	680-680-9
CAS No.	131707-23-8	Density	N/A
PSA	80.00000	LogP	5.97900
Solubility	N/A	Melting Point	133-137?C
Formula	C₂₂H₂₆BrClN₂O₃S	Boiling Point	591.8 ºC at 760 mmHg
Molecular Weight	513.883	Flash Point	311.7 ºC
Transport Information	N/A	Appearance	White or off-white crystalline powder
Safety	26	Risk Codes	36/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	1H-Indole-3-carboxylicacid, 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester, monohydrochloride(9CI);Arbidol;Arbidolhydrochloride;	Article Data	2

Arbidol hydrochloride Synthetic route

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

: 131707-24-9
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Stage #1: formaldehyd; dimethyl amine; 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester With aminosulfonic acid In water at 30 - 40℃; for 3h; Cooling with ice; Stage #2: With hydrogenchloride In water; acetone at 60℃; pH=1;	85.6%

: 131707-25-0
arbidol

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In acetone for 0.5h; Reflux;	75%

: C14H17NO4

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 3.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 4.1: sodium hydroxide / methanol / 2 h 4.2: 3 h 5.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 5.2: 60 °C / pH 1 View Scheme

Yield

Multi-step reaction with 5 steps
1.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
3.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
4.1: sodium hydroxide / methanol / 2 h
4.2: 3 h
5.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice
5.2: 60 °C / pH 1
View Scheme

: 20862-91-3
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 2.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 3.1: sodium hydroxide / methanol / 2 h 3.2: 3 h 4.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 4.2: 60 °C / pH 1 View Scheme

: 40945-79-7
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 2.1: sodium hydroxide / methanol / 2 h 2.2: 3 h 3.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 3.2: 60 °C / pH 1 View Scheme
Multi-step reaction with 4 steps 1.1: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere 2.1: potassium hydroxide; methanol / 0.25 h / 20 °C 2.2: 4 h / 20 °C 3.1: acetic acid / water / 0.25 h / 0 °C 3.2: 4 h / 80 °C 4.1: hydrogenchloride / acetone / 0.5 h / Reflux View Scheme

: 100-02-7
4-nitro-phenol

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: pyridine / acetone / 4 h / 20 °C / Reflux 2.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 3.1: indium(III) bromide / dichloromethane / 3 h / Reflux 4.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 6.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 7.1: sodium hydroxide / methanol / 2 h 7.2: 3 h 8.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 8.2: 60 °C / pH 1 View Scheme

Yield

Multi-step reaction with 8 steps
1.1: pyridine / acetone / 4 h / 20 °C / Reflux
2.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux
3.1: indium(III) bromide / dichloromethane / 3 h / Reflux
4.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
6.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
7.1: sodium hydroxide / methanol / 2 h
7.2: 3 h
8.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice
8.2: 60 °C / pH 1
View Scheme

: 830-03-5
4-nitrophenol acetate

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 2.1: indium(III) bromide / dichloromethane / 3 h / Reflux 3.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 5.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 6.1: sodium hydroxide / methanol / 2 h 6.2: 3 h 7.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 7.2: 60 °C / pH 1 View Scheme

Yield

Multi-step reaction with 7 steps
1.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux
2.1: indium(III) bromide / dichloromethane / 3 h / Reflux
3.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
5.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
6.1: sodium hydroxide / methanol / 2 h
6.2: 3 h
7.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice
7.2: 60 °C / pH 1
View Scheme

: 13871-68-6
p-aminophenyl acetate

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: indium(III) bromide / dichloromethane / 3 h / Reflux 2.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 4.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux 5.1: sodium hydroxide / methanol / 2 h 5.2: 3 h 6.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice 6.2: 60 °C / pH 1 View Scheme

Yield

Multi-step reaction with 6 steps
1.1: indium(III) bromide / dichloromethane / 3 h / Reflux
2.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
4.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
5.1: sodium hydroxide / methanol / 2 h
5.2: 3 h
6.1: aminosulfonic acid / water / 3 h / 30 - 40 °C / Cooling with ice
6.2: 60 °C / pH 1
View Scheme

: 15574-49-9
mecarbinate

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: 4 h / Reflux 2.1: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere 3.1: potassium hydroxide; methanol / 0.25 h / 20 °C 3.2: 4 h / 20 °C 4.1: acetic acid / water / 0.25 h / 0 °C 4.2: 4 h / 80 °C 5.1: hydrogenchloride / acetone / 0.5 h / Reflux View Scheme

: 110543-98-1
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

: 131707-23-8
Arbidol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium hydroxide; methanol / 0.25 h / 20 °C 1.2: 4 h / 20 °C 2.1: acetic acid / water / 0.25 h / 0 °C 2.2: 4 h / 80 °C 3.1: hydrogenchloride / acetone / 0.5 h / Reflux View Scheme

Arbidol hydrochloride Chemical Properties

The Molecular Structure of Arbidol hydrochloride (CAS NO.131707-23-8):

Empirical Formula: C₂₂H₂₆BrClN₂O₃S
Molecular Weight: 513.8754
Flash Point: 311.7 °C
Enthalpy of Vaporization: 91.52 kJ/mol
Boiling Point: 591.8 °C at 760 mmHg
Vapour Pressure: 1.34E-14 mmHg at 25°C
Synonyms: 6-Bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid ethyl ester monohydrochloride

Arbidol hydrochloride Uses

Arbidol hydrochloride (CAS NO.131707-23-8) is a medicinal agent for treating viral infections.

Arbidol hydrochloride Production

1,2-Dimethyl-5-hydroxyindole-3-acetic acid ethyl ester (I) is acetylated with acetic anhydride affording the O-acyl derivative (II) , which is brominated to the corresponding dibromide compound (III) . The reaction of (III) with thiophenol in KOH yields (IV) , which is then submitted to a conventional Mannich condensation with formaldehyde and dimethylamine in acetic acid, giving the free base of arbidol (V), which is treated with aqueous hydrochloric acid .

Arbidol hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	oral	> 3gm/kg (3000mg/kg)	Drugs of the Future. Vol. 17, Pg. 1079, 1992.
mouse	LD50	oral	340mg/kg (340mg/kg)	Drugs of the Future. Vol. 17, Pg. 1079, 1992.
rat	LD50	oral	> 3gm/kg (3000mg/kg)	Drugs of the Future. Vol. 17, Pg. 1079, 1992.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 131707-23-8