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Azosemide

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Name

Azosemide

EINECS 248-549-7
CAS No. 27589-33-9 Density 1.661g/cm3
PSA 163.27000 LogP 3.69520
Solubility N/A Melting Point 218-221°
Formula C12H11 Cl N6 O2 S2 Boiling Point 671.1°Cat760mmHg
Molecular Weight 370.843 Flash Point 359.6°C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl, SOx, and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 27589-33-9 (Azosemide) Hazard Symbols N/A
Synonyms

Benzenesulfonamide,2-chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]- (9CI); Sulfanilamide,2-chloro-5-(1H-tetrazol-5-yl)-N4-2-thenyl- (8CI);2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide;5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole; Azosemide; Diart;Diurapid; Luret; Ple 1053; SK 110; SK 110 (pharmaceutical)

 

Azosemide Chemical Properties

Chemical Name: Azosemide
IUPAC NAME: 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
CAS No.: 27589-33-9
EINECS: 248-549-7
Molecular Formula: C12H11ClN6O2S2
Molecular Weight: 370.84 g/mol
Density: 1.661 g/cm3
Flash Point: 359.6 °C
Boiling Point: 671.1 °C at 760 mmHg
Following is the structure of Azosemide (CAS No.27589-33-9):


The chemical synonymous of Azosemide (CAS No.27589-33-9) are 2-Chloro-5-(1H-Tetrazol-5-Yl)-4-((2-Thienylmethyl)Amino)-Benzenesulfonamid ; 2-Chloro-5-(1H-Tetrazol-5-Yl)-N(Sup4)-2-Thenyl-Sulfanilamid ; 2-Chloro-5-(1h-Tetrazol-5-Yl)-N(Sup4)-2-Thenylsulfanilamide ; 5-(4’-Chloro-5’-Sulfamoyl-2’-Thenylaminophenyl)-Tetrazole ; Azosemid ; Ple1053 ; Azosemide ; 2-Chloro-5-(1H-Tetrazol-5-Yl)-4-(2-Thenylamino)Benzenesulphonamide

Azosemide Toxicity Data With Reference

1.    

orl-rat LD50:2545 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666.
2.    

ipr-rat LD50:287 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666.
3.    

ivn-rat LD50:252 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666.
4.    

orl-mus LD50:6350 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666.
5.    

scu-mus LD50:762 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666.

Azosemide Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl, SOx, and NOx.

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