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BENZOTHIAZIDE

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Name

BENZOTHIAZIDE

EINECS N/A
CAS No. 91-33-8 Density 1.66g/cm3
PSA 160.75000 LogP 4.86900
Solubility 2.8mg/L(room temperature) Melting Point 231-232° (U.S. patent); mp 238-239° (P'an)
Formula C15H14 Cl N3 O4 S3 Boiling Point 680.6°C at 760 mmHg
Molecular Weight 431.945 Flash Point 365.4°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous route. A diuretic and antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl. Risk Codes 42/43
Molecular Structure Molecular Structure of 91-33-8 (BENZTHIAZIDE) Hazard Symbols
Synonyms

2H-1,2,4-Benzothiadiazine-7-sulfonamide,3-[(benzylthio)methyl]-6-chloro-, 1,1-dioxide (6CI,8CI);3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;3-Benzylthiomethyl-6-chloro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;3-[(Benzylthio)methyl]-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; Aquatag; Benzothiazide; Benzthiazide; Dihydrex; Diucen; Diucene;Edemex; ExNa; Exosalt; Fovane; Freeuril; HyDrine; Lemazide; P 1393; Pfizer1393; Proaqua; Regulon; Urese

 

BENZOTHIAZIDE Chemical Properties

Chemical Formula C15H14ClN3O4S3

BENZOTHIAZIDE Uses

Benzothiazide is used to treat hypertension and edema.

BENZOTHIAZIDE Toxicity Data With Reference

1.   

ivn-rat LD50:422 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122.
2.   

ivn-mus LD50:410 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122.
3.   

ivn-dog LDLo:200 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122.

BENZOTHIAZIDE Safety Profile

Poison by intravenous route. A diuretic and antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl.
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