BEVANTOLOL HYDROCHLORIDE (42864-78-8),BEVANTOLOL HYDROCHLORIDE (42864-78-8) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-, hydrochloride(1:1)
Superlist Name:
Bevantolol hydrochloride
CAS No.:
42864-78-8
Molecular Structure:
Formula:
C₂₀H₂₇NO₄^.HCl
Molecular Weight:
381.90
Synonyms:
2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-, hydrochloride(9CI);1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanolhydrochloride;Bevantolol hydrochloride;CI 775;Cl 775;NC 1400;Ranestol;Sentiloc;Vantol;1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol hydrochloride (1:1);
Boiling Point:
518.3 °C at 760 mmHg
Flash Point:
267.3 °C

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Chemistry

Molecular Structure of BEVANTOLOL HYDROCHLORIDE (42864-78-8):

IUPAC Name: 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol hydrochloride
Molecular Formula:C₂₀H₂₈ClNO₄
Molecular Weight:381.893620 g/mol
Flash Point:267.3 °C
Enthalpy of Vaporization:83.26 kJ/mol
Boiling Point:518.3 °C at 760 mmHg
Vapour Pressure:1.44E-11 mmHg at 25 °C
Synonyms of BEVANTOLOL HYDROCHLORIDE (42864-78-8):
2-PROPANOL, 1-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]AMINO]-3-(3-METHYLPHENOXY)-, HYDROCHLORIDE ; 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol hydrochloride ; BEVANTOLOL HCL ; bevantolol hydrochloride ; BEVANTOLOLHYDROCHLORIDE(FORR&DONLY) ; 1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol hydrochloride ; CI 775 ; Cl 775

Uses

BEVANTOLOL HYDROCHLORIDE (42864-78-8) is used for the treatment of mild or moderate hypertension and angina pectoris.

Toxicity Data With Reference

1.	orl-rat LD50:460 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 26 (1995),364.
2.	ipr-rat LD50:130 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 26 (1995),364.
3.	ivn-rat LD50:25,100 µg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 26 (1995),364.
4.	orl-mus LD50:419 mg/kg	NCDREP New Cardiovascular Drugs. 3 (1985),85.
5.	orl-dog LD50:436 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 37 (1995),1835.

Safety Profile

A poison by intraperitoneal and intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x, HCl, and Cl⁻.