Basic information
- Name:
Benserazide hydrochloride
- CAS No.:
14919-77-8
- Molecular Structure:
- Formula:
- C10H15N3O5.HCl
- Molecular Weight:
- 293.74
- Deleted CAS:
- 14046-64-1|31796-68-6
- Synonyms:
- Serine,2-[(2,3,4-trihydroxyphenyl)methyl]- hydrazide,monohydrochloride;Ro 4-4602;Benserazide HCl;Serinehydrazide hydrochloride;Benserazide hydrochloride 98.5%;2'-(2,3,4-trihydroxybenzyl)-DL-serinohydrazide monohydrochloride;
- EINECS:
- 238-991-9
- Melting Point:
- 146 °C
- Boiling Point:
- 574.2 °C at 760 mmHg
- Flash Point:
- 301 °C
- Appearance:
- white crystalline solid
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-36 Details
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Chemistry
Product Name: Benserazide hydrochloride (CAS NO.14919-77-8)
Molecular Formula:C10H15N3O5·ClH
Molecular Weight:293.74
EINECS:238-991-9
Melting Point:146 °C
Boiling Point:574.2°C at 760mmHg
Flash Point:301°C
Solubility: H2O:10 mg/mL
Form:Solid
Chemical Properties:White Crystalline Solid
Enthalpy of Vaporization: 90.5 kJ/mol
Vapour Pressure: 5.06E-14 mmHg at 25°C
Structure Descriptors of Benserazide hydrochloride (CAS NO.14919-77-8):
IUPAC Name: 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazidehydrochloride
Canonical SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O.Cl
InChI: InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChIKey: ULFCBIUXQQYDEI-UHFFFAOYSA-N
Uses
Benserazide hydrochloride (CAS NO.14919-77-8) can be used as a peripheral decarboxylase inhibitor and antiparkinsonian.
Toxicity Data With Reference
| 1. | mmo-sat 1 mg/plate | RCOCB8 Research Communications in Chemical Pathology and Pharmacology. 49 (1985),415. | ||
| 2. | mma-sat 1 mg/plate | RCOCB8 Research Communications in Chemical Pathology and Pharmacology. 49 (1985),415. | ||
| 3. | orl-rat LD50:5800 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),181. | ||
| 4. | ipr-rat LD50:2150 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),181. | ||
| 5. | scu-rat LD50:2910 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),181. | ||
| 6. | orl-mus LD50:5 g/kg | KSRNAM Kiso to Rinsho. Clinical Report. 11 (1977),62. | ||
| 7. | ipr-mus LD50:1700 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 11 (1977),62. | ||
| 8. | scu-mus LD50:3300 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),181. |
Safety Profile
Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.
Safety Information of Benserazide hydrochloride (CAS NO.14919-77-8)
Hazard Codes Xi 
Risk Statements 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements 26-36
26: Very toxic by inhalation
36: Irritating to eyes
WGK Germany 2
RTECS VT9632300
Specification
Benserazide hydrochloride (CAS NO.14919-77-8) , the synonyms are 2'-(2,3,4-Trihydroxybenzyl)-dl-serinohydrazide monohydrochloride ; 2-(2,3,4-Trihydroxybenzyl)hydrazide,monohydrochloride,dl-serin ; Dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide,monohydrochloride .
