Basic information
- Name:
Berberine hydrochloride
- CAS No.:
633-65-8
- Molecular Structure:
- Formula:
- C20H18NO4.Cl
- Molecular Weight:
- 371.84
- Synonyms:
- NSC 646666;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride (9CI);Berberine, chloride (6CI,7CI);Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride (8CI);Berberinium chloride;
- EINECS:
- 211-195-9
- Melting Point:
- 204-206 °C (dec.)
- Solubility:
- soluble in cold water
- Appearance:
- yellow crystalline powder
- Hazard Symbols:
Xn- Risk Codes:
- 20/21/22-36/37/38
- Safety Description:
- 24/25-36-26 Details
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Chemistry
Product Name: Berberine hydrochloride (CAS NO.633-65-8)
Molecular Formula: C20H18NO4.Cl
Molecular Weight: 371.82g/mol
Mol File: 633-65-8.mol
EINECS: 211-195-9
Appearance: yellow crystalline powder
Melting Point: 204-206 °C (dec.)
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Berberine hydrochloride (CAS NO.633-65-8):
Canonical SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13
(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M
Product Categories: Natural Plant Extract
Uses
An ingredient in some commercial eyewash products.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 37mg/kg (37mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 253, 1952. |
| mouse | LD50 | oral | > 29586mg/kg (29586mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974. |
| mouse | LD50 | unreported | 30mg/kg (30mg/kg) | Pharmaceutical Chemistry Journal Vol. 22, Pg. 856, 1988. | |
| rat | LD50 | intravenous | 60mg/kg (60mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 335, 1990. | |
| rat | LD50 | oral | > 15gm/kg (15000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Safety Information of Berberine hydrochloride (CAS NO.633-65-8):
Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1544
WGK Germany: 2
RTECS: DR9866400
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
Specification
Berberine hydrochloride , its CAS NO. is 633-65-8, the synonyms are 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride hydrate ; Benzodioxide ; Berberine chloride ; Berberinium chloride ; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride ; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride .