Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Bicine

Related Products

Hot Products

Name

Bicine

EINECS 205-755-1
CAS No. 150-25-4 Density 1.31 g/cm3
PSA 81.00000 LogP -1.64240
Solubility water: 1 M at 20 °C, clear, colorless Melting Point 190 °C (dec.)(lit.)
Formula C6H13NO4 Boiling Point 388.5 °C at 760 mmHg
Molecular Weight 163.174 Flash Point 188.8 °C
Transport Information N/A Appearance White crystalline powder
Safety 24/25-36-26 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 150-25-4 (Bicine) Hazard Symbols HarmfulXn
Synonyms

N,N-Bis(2-hydroxyethyl)glycine;Bis(2-Hydroxyethyl)glycine;N,N-Bis(2-hydroxyethyl)aminoacetic acid;NSC 7342;Diethanol glycine;

Article Data 22

Bicine Synthetic route

111-42-2

2,2'-iminobis[ethanol]

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
In ethanol; water at 70℃; for 16h;96%
75-21-8

oxirane

459-73-4

GlyOEt*HCl

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
at 25℃;
at 25℃; im Rohr;
5038-12-0

4-(2-hydroxy-ethyl)-morpholin-2-one

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With water at 25℃; Rate constant; at pD 7.0; hydrolysis also in humid air;
With water at 120℃;
With water (heating);
With water
98486-41-0

N,N-bis-(2-chloro-ethyl)-glycine

A

86240-92-8

4-(2-chloro-ethyl)-morpholin-2-one

B

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With sodium hydrogencarbonate; benzene
With sodium hydrogencarbonate
64-69-7

Iodoacetic acid

111-42-2

2,2'-iminobis[ethanol]

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With methanol
3926-62-3

sodium monochloroacetic acid

111-42-2

2,2'-iminobis[ethanol]

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With water
111-42-2

2,2'-iminobis[ethanol]

79-11-8

chloroacetic acid

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With ethanol
In ethanol

Nα,Nα-bis(-2-hydroxyethyl)glycine amide

A

5038-12-0

4-(2-hydroxy-ethyl)-morpholin-2-one

B

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With water at 25℃; Rate constant; Product distribution; Mechanism; pH varied: 4 to 8; hydrolysis of C-terminal amide group of various α-aminoacids having one or two hydroxyethyl groups at N-terminal, via cyclization to a morpholinolactone; reaction monitored by 1H NMR;
5038-12-0

4-(2-hydroxy-ethyl)-morpholin-2-one

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

<2-chloroacetoxy-ethyl>-<2-chloro-ethyl>-amine hydrochloride

<2-chloroacetoxy-ethyl>-<2-chloro-ethyl>-amine hydrochloride

150-25-4

N,N-bis-(2-hydroxyethyl)glycine

Conditions
ConditionsYield
With potassium carbonate

Bicine Specification

The Bicine is an organic compound with the formula C6H13NO4. The IUPAC name of this chemical is 2-[bis(2-hydroxyethyl)amino]acetic acid. With the CAS registry number 150-25-4 and EINECS 205-755-1, it is also named as N,N-Bis(2-hydroxyethyl)glycine. The product's categories are Biochemistry; Good's Buffers; Buffer. It is white crystalline powder which is stable under normal temperature and pressure. Additionally, this chemical should be stored at normal temperature.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.48; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.96; (4)ACD/LogD (pH 7.4): -2.99; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 48 Å2; (13)Index of Refraction: 1.525; (14)Molar Refractivity: 38.2 cm3; (15)Molar Volume: 124.4 cm3; (16)Polarizability: 15.14×10-24 cm3; (17)Surface Tension: 63.8 dyne/cm; (18)Density: 1.31 g/cm3; (19)Flash Point: 188.8 °C; (20)Enthalpy of Vaporization: 73.75 kJ/mol; (21)Boiling Point: 388.5 °C at 760 mmHg; (22)Vapour Pressure: 1.21E-07 mmHg at 25°C.

Preparation of Bicine: It can be obtained by 2,2'-azanediyl-bis-ethanol and glyoxal. This reaction needs solvents H2O, ethanol at temperature of 70 °C. The reaction time is 16 hours. The yield is 96%. 

Bicine can be obtained by 2,2'-azanediyl-bis-ethanol and glyoxal

Uses of Bicine: It is used as a buffering agent in biochemical research. And it can react with acetic acid anhydride to get 4-(2-acetoxy-ethyl)-morpholin-2-one. This reaction needs reagent Et3N by heating. The reaction time is 1 hours. The yield is 83%.

Bicine can react with acetic acid anhydride to get 4-(2-acetoxy-ethyl)-morpholin-2-one

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure. 
1. SMILES:O=C(O)CN(CCO)CCO
2. InChI:InChI=1/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
3. InChIKey:FSVCELGFZIQNCK-UHFFFAOYAV

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1540mg/kg (1540mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Revue d'Epidemiologie, Medecine Sociale et Sante Publique. Vol. 10, Pg. 391, 1962.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 150-25-4