Basic information
- Name:
Buflomedil hydrochloride
- CAS No.:
35543-24-9
- Molecular Structure:
- Formula:
- C17H25NO4.HCl
- Molecular Weight:
- 343.89
- Synonyms:
- 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one hydrochloride;Fonzylane;Irrodan R;Prestwick_782;LL 1656;1-Butanone,4-(1-pyrrolidinyl)-1-(2,4,6- trimethoxyphenyl)-,hydrochloride;Buflomedil HCl;1-[3-(2,4,6-trimethoxybenzoyl)propyl]pyrrolidinium chloride;A-48257;
- EINECS:
- 252-611-9
- Boiling Point:
- 454.5 °C at 760 mmHg
- Flash Point:
- 228.7 °C
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Chemistry
Product Name: Buflomedil hydrochloride (CAS NO.35543-24-9)
Molecular Formula: C17H25NO4.HCl
Molecular Weight: 343.85g/mol
Mol File: 35543-24-9.mol
EINECS: 252-611-9
Boiling point: 454.5 °C at 760 mmHg
Flash Point: 228.7 °C
Enthalpy of Vaporization: 71.41 kJ/mol
Vapour Pressure: 1.9E-08 mmHg at 25°C
H-Bond Donor: 1
H-Bond Acceptor: 5
Structure Descriptors of Buflomedil hydrochloride (CAS NO.35543-24-9):
IUPAC Name: 4-pyrrolidin-1-ium-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one chloride
Canonical SMILES: COC1=CC(=C(C(=C1)OC)C(=O)CCC[NH+]2CCCC2)OC.[Cl-]
InChI: InChI=1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H
InChIKey: ZDPACSAHMZADFZ-UHFFFAOYSA-N
Product Categories: APIs; API
Uses
Buflomedil hydrochloride (CAS NO.35543-24-9) is a drug for cerebrovascular expansion
Toxicity Data With Reference
| 1. | orl-wmn TDLo:50 mg/kg:BAH,SYS | JTCTDW Journal of Toxicology, Clinical Toxicology. 30 (1992),305. | ||
| 2. | orl-rat LD50:410 mg/kg:BAH,PUL | KSRNAM Kiso to Rinsho. Clinical Report. 22 (1988),401. | ||
| 3. | scu-rat LD50:796 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 22 (1988),401. | ||
| 4. | ivn-rat LD50:58,500 µg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 22 (1988),401. | ||
| 5. | orl-mus LD50:275 mg/kg | THERAP Therapie. 30 (1975),207. | ||
| 6. | ivn-mus LD50:55 mg/kg | THERAP Therapie. 30 (1975),207. | ||
| 7. | ims-mus LD50:250 mg/kg | THERAP Therapie. 30 (1975),207. | ||
| 8. | orl-dog LDLo:500 mg/kg | THERAP Therapie. 30 (1975),207. | ||
| 9. | ivn-dog LDLo:50 mg/kg | THERAP Therapie. 30 (1975),207. |
Safety Profile
Safety Information of Buflomedil hydrochloride (CAS NO.35543-24-9):
K Germany: 3
RTECS: EL9885000
Specification
Buflomedil hydrochloride , its CAS NO. is 35543-24-9, the synonyms are 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride ; Bufedil ; Buflan ; Buflomedil HCl ; Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3)
propylacetone ; 1-(3-(2,4,6-Trimethoxybenzoyl)propyl)pyrrolidinium chloride ; 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-, hydrochloride .