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Basic information

  • Name:

  • Ethanaminium,2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (1:1)

  • Superlist Name:
  • Carbachol
  • CAS No.:

  • 51-83-2

  • Formula:
  • C6H15 N2 O2 . Cl
  • Synonyms:
  • Choline,chloride, carbamate (6CI,8CI); Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-,chloride (9CI); (2-Carbamoyloxyethyl)trimethylammonium chloride;(2-Hydroxyethyl)trimethyl ammonium chloride carbamate; Carbachol; Carbacholchloride; Carbacholin; Carbacholine; Carbacholine chloride; Carbacolina;Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamiotin;Carbamoylcholine chloride; Carbamoylcholine-hydrochloride; Carbamylcholinechloride; Carbastat Intraocular; Carbochol; Carbocholin; Carbocholine; Carbyl;Carcholin; Choline carbamate chloride; Coletyl; Doryl; Doryl (pharmaceutical);Isopto Carbachol; Jestryl; Lentin; Miostat; Moryl; Vasoperif; g-Carbamoyl choline chloride

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Chemistry

Carbachol chloride(51-83-2) exists as white crystals, insoluble in CHCl3 and Et2O. Carbachol chloride(51-83-2) has hydroscopic property and smells like fatty amines.
Molecular Structure:
Molecular Formula: C6H15N2O2?Cl.
Molecular Weight: 182.68.
Melting Point: 200-204 ℃.
Solubility(H2O): 1.0 g/mL.

Uses

Carbachol chloride(51-83-2) is a kind of cholinergic drugs, and it is also used as parasympathetic stimulant. As a animal remedy, Carbachol chloride(51-83-2) is used for the treatment of intestinal colic.

Toxicity Data With Reference

1.   

ivn-man TDLo:1428 ng/kg:CVS,GIT

   CRSBAW    Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 113 (1933),79.
2.   

ims-hmn TDLo:6 µg/kg:EYE,CVS,SKN

   SCALA9    Scalpel. 36 (1933),1.
3.   

ims-man TDLo:2857 ng/kg:CVS

   CRSBAW    Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 113 (1933),79.
4.   

orl-rat LD50:40 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
5.   

ipr-rat LD50:2 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 149 (1964),560.
6.   

scu-rat LD50:4 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
7.   

ivn-rat LD50:100 µg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
8.   

orl-mus LD50:15 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),182.
9.   

ipr-mus LD50:370 µg/kg

   ATXKA8    Archiv fuer Toxikologie. 29 (1972),39.
10.   

scu-mus LD50:3 mg/kg

Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Safety Profile

Deadly poison by subcutaneous, intravenous, and intraperitoneal routes. Poison by ingestion and possibly other routes. Human systemic effects by intravenous and intramuscular routes including: lowered blood pressure, venous dilation, nausea or vomiting, sweating and lachrymation (increased flow of tears). A cholinergic agent (parasympathetic nerve stimulant). When heated to decomposition it emits very toxic fumes of Cl−, NH3, and NOx. See also CARBAMATES.

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