Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (21704-46-1),Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (21704-46-1) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Carbamimidothioic acid, ethyl ester, diethyl phosphate (1:1)
CAS No.:
21704-46-1
Molecular Structure:
Formula:
C4 H11 O4 P . C3 H8 N2 S
Molecular Weight:
258.31
Synonyms:
Carbamimidothioic acid, ethyl ester, mono(diethyl phospate);diethoxyphosphinic acid; ethylsulfanylmethanimidamide;S-Ethylisothiuronium diethyl phosphate;Phosphoric acid, diethyl ester, compd. with 2-ethyl-2-thiopseudourea (1:1);
Safety Description:
Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NO_x, PO_x, and SO_x. See also ESTERS and PHOSPHATES. Details

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Chemistry

IUPAC Name: Diethyl hydrogen phosphate; ethyl carbamimidothioate
Molecular Formula: C₄H₁₁O₄P•C₃H₈N₂S
Molecular Weight: 258.31g/mol
Boiling Point: 200.3 °C at 760 mmHg
Flash Point: 74.9 °C
Freely Rotating Bonds: 4
Polar Surface Area: 54.57 Å²
Enthalpy of Vaporization: 48.11 kJ/mol
Vapour Pressure: 0.137 mmHg at 25°C
The Cas Register Number of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) is 21704-46-1.The chemical synonyms of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) are S-Ethylisothiuronium diethyl phosphate ; CID210823 ; LS-107705 ; Carbamimidothioic acid, ethyl ester, mono(diethyl phospate) ; Phosphoric acid, diethyl ester, compd. with 2-ethyl-2-thiopseudourea (1:1) .The molecular structure of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) is .

Uses

Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) is used as pharmaceutical intermediate.

Toxicity Data With Reference

1.	ipr-rat LD50:113 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212.
2.	orl-mus LD50:2380 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212.
3.	ipr-mus LD50:680 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212.
4.	scu-mus LD50:705 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212.
5.	ims-mus LD50:772 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NO_x, PO_x, and SO_x. See also ESTERS and PHOSPHATES.

Specification

Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) has been shown to phosphorylate other proteins in vitro including the eukaryotic initiation factor eIF-2B at Serine540 .This phosphorylation results in an inhibition of eIF-2B activity and leads to a reduction in this key regulatory step of translation. In disease states, such as diabetes, where there is elevated Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) could result in a reduction of translation and potentially contribute to the pathology of the disease.