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Basic information

  • Name:

  • Carvedilol

  • CAS No.:

  • 72956-09-3

  • Formula:
  • C24H26N2O4
  • Synonyms:
  • 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-;Carvedilolum [Latin];Carvedilol [USAN:BAN:INN:JAN];Coreg (TN);Carvedilol (JAN/USAN);2-Propanol,1-(9H-carbazol-4-yloxy)-3-[[2- (2-methoxyphenoxy)ethyl]amino]-;SKF 105517;(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol;DQ 2466;1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;

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Chemistry

Structure of Carvedilol (CAS NO.72956-09-3): 

IUPAC Name: 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol 
Empirical Formula: C24H26N2O4
Molecular Weight: 406.4742g/mol
Index of Refraction: 1.657
Molar Refractivity: 119.59 cm3
Molar Volume: 325.1 cm3
Polarizability: 47.41×10-24cm3
Surface Tension: 53.9 dyne/cm
Density: 1.25 g/cm3
Flash Point: 350.1 °C
Enthalpy of Vaporization: 101.39 kJ/mol 
Melting Point: 113-117°C
Boiling Point: 655.2 °C at 760 mmHg
Vapour Pressure: 4.63E-18 mmHg at 25°C 
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Adrenoceptor 
Canonical SMILES: COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
InChIKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N

Uses

 Carvedilol (CAS NO.72956-09-3) is a beta blocker and an alpha blocker indicated in the treatment of mild to moderate congestive heart failure (CHF).

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
mouse LD50 intraperitoneal 364mg/kg (364mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LD50 intravenous 27mg/kg (27mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LDLo oral 8gm/kg (8000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
rat LD50 intraperitoneal 769mg/kg (769mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LD50 intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LDLo oral 8gm/kg (8000mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.

Safety Profile

Hazard Codes of Carvedilol (CAS NO.72956-09-3): DangerousN,HarmfulXn
Risk Statements: 51/53-36/37/38-20/21/22
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 61-36-26
S61: Avoid release to the environment. Refer to special instructions / safety data sheets. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3077 9/PG 3
RTECS: UA8670000

Specification

 Carvedilol , its cas register number is 72956-09-3. It also can be called (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-
methoxyphenoxy)ethyl)amino)-2-propanol ; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol ;
 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)- ; BM 14190 ; Carvedilolum ; Coreg ;
 DQ 2466 ; HSDB 7044 ; SKF 105517 ; UNII-0K47UL67F2 . Carvedilol (CAS NO.72956-09-3) is a colourless crystalline solid. Side effects of carvedilol were observed to include nightmares,sleep disturbances and anxiety and panic attacks. This is based on a single case report of a patient already diagnosed with anxiety disorder and using the drug improperly before bedtime at elevated doses.

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