- NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST
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The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.
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Paragraph 0064
(2014/03/21)
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- Improved syntheses of phosphine ligands by direct coupling of diarylbromophosphine with organometallic reagents
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Br versus Cl: It is found that the use of diarylbromophosphines instead of diarylchlorophosphines is crucial for their direct coupling with binaphthylmagnesium bromide or BINOL triflate. This finding has led to an improved preparation of both electron-deficient BINAP-type phosphine ligands and several important Buchwald's ligands. Copyright
- Liu, Lei,Wu, Hai-Chen,Yu, Jin-Quan
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scheme or table
p. 10828 - 10831
(2011/11/04)
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- Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor
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(Chemical Equation Presented) A new protocol for deoxygenation of various phosphine oxides with retention of configuration is described. The advantage of the new method includes milder conditions and considerably shortened reaction times. Mechanistic studies about the oxygen transfer between the starting phosphine oxide and the sacrificial triphenylphosphine are also presented.
- Wu, Hai-Chen,Yu, Jin-Quan,Spencer, Jonathan B.
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p. 4675 - 4678
(2007/10/03)
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- PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS
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A production method of a_compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
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- Ruthenium-I0D0-optically active phosphine complex
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This invention is concerned with a ruthenium-iodo-optically active bidentate phosphine complex of the formula (I):[Ru-(I)q-(T1)n(SOL)r(L)]m(T2)p(I)s(I)wherein T1 represents a carboxylic acid anion, SOL represents a polar solvent, L represents an optically active bidentate phosphine ligand, T2 represents an anion different from halogen atom anions and carboxylic acid anions, n denotes 0 or 1, r denotes 0, 3 or 4, m denotes 1 or 2, q denotes 0 or 1, or where m is 2, q may represent 1 or 1.5, p denotes 0 or 1, and s denotes 0, 1 or 2 is prepared. Said phosphine complex is usefull as an efficient catalyst for asymmetrically hydrogenating 4-methylene-2-oxetanone into optically active 4-methyl-2-oxetanone.
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- Process for producing optically active benzhydrol compounds
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A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: STR1 wherein R1 to R10 each represents H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl, etc., R2 and R3, and R8 and R9 may form --CH=CH--CH=CH--, or any two of R1 to R9 adjacent to each other may be bonded to thereby form --OCH2 O-- or --(CH2)3 --. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.
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- Process for preparing an optically active amine
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A novel process for preparing an optically active amine by asymmetric hydrogenation of an imine compound, such as an imine compound prepared by condensing benzylamine and acetophenone, in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative. The present invention provides an optically active amine of high optical purity.
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- N-substituted-7-amino-5-hydroxy-3-oxoheptanoic acid derivatives and method for producing the same
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Compounds represented by the following general structural formula (1) and methods for producing the compounds: STR1 R1 represents a group such as benzyloxycarbonyl, R2 represents a lower alkyl group, R3 represents a hydrogen atom or a protecting group, each of M1 and M2 represents a metal atom, and n represents the atomic valence of M1. Intermediates for HMG-CoA reductase inhibitors can be prepared safely and easily from these compounds.
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- Process for preparing optically active 4-methyl-2-oxetanone
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A process for preparing optically active 4-methyl-2-oxetanone which comprises asymmetrically hydrogenating 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex. Optically active 4-methyl-2-oxetanone can easily and economically be obtained at high optical purity.
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- Process for preparing optically active 4-methyl-2-oxetanone
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A process for preparing optically active 4-methyl-2-oxetanone which comprises asymmetrically hydrogenating 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex. Optically active 4-methyl-2-oxetanone can easily and economically be obtained at high optical purity.
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- Ruthenium-phosphine complex
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A ruthenium-phosphine complex represented by the formula (I) wherein R--BINAP represents tertiary phosphine represented by the formula (II) STR1 R which is the same represents hydrogen, methyl or t-butyl, S represents tertiary amine, y represents 0 or 1, and when y is 0, x represents 2, z represents 4 and p represents 1, and when y is 1, x represents 1, z represents 1 and p represents 0.
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- Practical Synthesis of (R)- or (S)-2,2'-Bis(diarylphosphino)-1,1'-binaphthyls (BINAPs)
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Practical methods for the synthesis of (R)- or (S)-2,2'bis(diarylphosphino)-1,1'-binaphthyls (BINAPs), useful ligands for transition-metal-catalyzed asymmetric reactions, have been developed. (+/-)-2,2'-Bis(diphenylphosphinyl)1,1'-binaphthyl , prepared from 2,2'-dibromo-1,1'-binaphthyl and diphenylphosphinyl chloride, can be resolved into optical antipodes by the use of camphorsulfonic acid or 2,3-di-O-benzoyltartaric acid.Reduction of resolved BINAPO with trichlorosilane in the presence of triethylamine affords optically pure 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP).In a similar manner, several BINAP analogues have been prepared in optically pure form.The present procedures are suitable for obtaining these axially dissymmetric diphosphines in a large scale.The molecular structure of the 1:1:1 complex of (S)-(-)-BINAPO, (1R)-(-)-camphorsulfonic acid, and acetic acid has been studied by single-crystal X-ray analysis.
- Takaya, Hidemasa,Mashima, Kazushi,Koyano, Kinko
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p. 629 - 635
(2007/10/02)
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