Nickel-Catalyzed ortho-C-H Thiolation of N-Benzoyl α-Amino Acid Derivatives
We developed the first nickel-catalyzed direct ortho-thiolation of N-benzoyl α-amino acid derivatives. This novel strategy showed wide generality, functional tolerance, and high regioselectivity. In addition, dipeptide derivatives were also compatible with this transformation system, providing a potential protocol for the direct modification of peptide derivatives.
Gao, Feng,Zhu, Wei,Zhang, Dengyou,Li, Shuangjie,Wang, Jiang,Liu, Hong