- Benzotriazole: A novel synthetic auxiliary
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Benzotriazole and aldehydes react reversibly to give addition products: in the presence of amines and other NH-compounds water can be eliminated to form products of type Bt-CHR-NR′R″. The latter are versatile intermediates for the preparation of primary, secondary, and tertiary amines and in the alkylation of hydroxylamines, hydrazines, amides, thioamides, and sulfonamides. Polyfunctional amines and other polyfunctional compounds can also be prepared, and they enable significant extending of Mannich reaction. Similar oxygen compounds Bt-CRR′-OR″ enable new syntheses of ethers and esters. Reactions in which benzotriazole is eliminated rather than substituted open up new pathways to enamines, enol ethers, and nitrones. The methodology is capable of extension to a variety of vinylogous systems including benzenoid and heteroaromatic derivatives. In addition to acting as a versatile leaving group, benzotriazolyl residues activate neighboring CH bonds to proton loss and a variety of such applications is described.
- Katritzky, Alan R.,Rachwal, Stanislaw,Hitchings, Gregory J.
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p. 2683 - 2732
(2007/10/02)
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- Mixed metal bases as promoters of 1,4-eliminations
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When treated with the LIDAKOR mixture, allyl type ethers very readily undergo 1,4-elimination to afford conjugated dienes (3 - 73). In typical cases, the reaction is brought about stereo- and regioselectively (2 and 7, respectively). Under suitable conditions, lithium dimethylamide or even lithium diisopropylamide adds to the dienes generated in situ thus leading to a variety of new allyl amines (5-8).
- Margot, Christian,Matsuda, Hiroyuki,Schlosser, Manfred
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p. 2425 - 2430
(2007/10/02)
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- 1,3-Dipolar Cycloadditions, 90. Diphenylnitrilimine and Substituted Butadienes; Substituent Effects and Rate of Cycloaddition
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1-Substitued butadienes accept diphenylnitrilimine (2) not at the 1,2- but rather at the 3,4-double bond; the regiospecific cycloaddition furnishes 5-substituted 1,3-diphenyl-2-pyrazolines.The relative addition rates, measured in competition experiments,
- Fliege, Werner,Huisgen, Rolf,Kolbeck, Winfried,Weberndoerfer, Volkmar
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p. 3438 - 3460
(2007/10/02)
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