- Pyrazolopyrimidine compounds and preparation method thereof, and applications in preparation of anti-cancer drugs
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The invention provides a class of pyrazolopyrimidine compounds represented by a formula (I) or pharmaceutically acceptable salts thereof, and a preparation method thereof, and applications of the pyrazolopyrimidine compounds or the pharmaceutically accept
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Paragraph 0140-0142; 0158-0161
(2020/04/17)
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- Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
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Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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- Pyrrolobenzimidazoles for treating heart or circulatory diseases
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Pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions thereof for the treatment of coronary insufficiencies, cardiac failure, blood circulatory disturbances and occlusive diseases. The new pyrrolobenzimidazoles are of the formula STR1 wherein R1 is hydrogen, alkyl, alkenyl or cycloalkyl, R2 is hydrogen, alkyl, alkenyl, cyano or a substituted carbonyl or R1 and R2 together represent cycloalkylene or form alkylidene or cycloalkylidene, X is a valency bond, C1 -C4 alkylene or vinylene, T is oxygen or sulphur and Py is pyridyl or substituted pyridyl and including the tautomers thereof and the physiologically acceptable salts thereof.
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