ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant
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Page/Page column 39-40
(2021/11/06)
Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation
Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.
Qing, Zhang,Takacs, James M.
p. 545 - 548
(2008/09/17)
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