Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21
Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant-fatty acid amide analogues have been prepared. Synthesis of pyrazoles 2a-2c was achieved by a two steps simple methodology via α,β-unsaturated ketones. Carboxamides 8a-8h were obtained in good yields from esters 7a-7c by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic agents. Some of them showed interesting properties reducing food intake in rats by a mechanism which does not involve the endocannabinoid system.
Alvarado, Mario,Decara, Juan,Luque, María Jesús,Hernandez-Folgado, Laura,Gómez-Ca?as, María,Gómez-Ruiz, María,Fernández-Ruiz, Javier,Elguero, José,Jagerovic, Nadine,Serrano, Antonia,Goya, Pilar,De Fonseca, Fernando Rodríguez
p. 1708 - 1716
(2013/05/09)
An efficient and stereoselective synthesis of (E)-α-enones via arsonium salts. Preparation of key intermediates for the synthesis of brassinosteroid and prostaglandin
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Huang,Shi,Li
p. 975 - 977
(2007/10/02)
An Improved Procedure for the Claisen-Shmidt Reaction
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Sinisterra, J. V.,Garcia-Raso, A.,Cabello, J. A.,Marinas, J. M.
p. 502 - 504
(2007/10/02)
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