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Design, synthesis, and cytotoxicity of novel 2,4,6-trisubstituted 1,3,5-triazines bearing aryl hydrazone moiety as potent antitumor agent
A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing aryl hydrazone moiety were designed and synthesized under the guidance of scaffold hopping and bioisosterism from the autophagy inhibitor VLX600. The target compounds were evaluated for cytotoxicity against HT-29 by MTT assay with VLX600 as positive control. Then, ten potent target compounds (5c-5f, 5i-5r, 5s, 5t) were further evaluated against two cancer cell lines H460 and A549 and one normal cell line WI-38. Most of them exhibited significant cytotoxicity against one or more cell lines. Particularly, a promising compound 5f was identified, which exhibited the most potent cytotoxicity against HT-29, H460 and A549 cancer cell lines with IC50 values of 0.047 μM, 0.071 μM and 0.071 μM, respectively, which was 10-to 62-folds more potent than VLX600 (IC50 = 0.47 μM, 4.1 μM, 4.4 μM). The preliminary structure-activity relationships (SARs) of the compounds were also discussed.
Wang, Limei,Zhao, Sijia,Bao, Guanglong,Zhang, Yu,Xi, Shuancheng,Zhou, Guolin,Zhai, Xin,Gong, Ping
p. 621 - 630
(2016/10/18)

HEXAHYDROTRIAZINES, SYNTHESIS AND USE
Methods for making asymmetrical triazines are provided. The methods comprise first forming a mixture of at least two primary amines then reacting the mixture with an aldehyde. Methods for removing sulfides from hydrocarbon streams are also provided. The triazines may be added to the hydrocarbon stream in a molar ratio of triazine:H2S of about 10:1 to about 1:2.
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(2013/05/22)

Targeting the hydrophobic region of Hsp90's ATP binding pocket with novel 1,3,5-triazines
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in regulating the maturation and stabilization of many oncogenic proteins. In an attempt to discover a new class of Hsp90 inhibitors, a series of 1,3,5-triazine compounds were rationally designed, synthesized, and their biological activities were evaluated. Compound 3b was found to degrade Hsp90's client proteins of Her2, Met and Akt and to induce the expression level of Hsp70. The binding mode of 3b in the ATP-binding site of Hsp90 was predicted by the molecular docking.
Lee, Taeho,Seo, Young Ho
supporting information
p. 6427 - 6431
(2013/11/19)

Dyes and their use in ink-jet printing
A compound of Formula (1) or a salt thereof: wherein: A is optionally substituted aryl or optionally substituted heterocyclyl; and R1 and R2 are independently H or a substituent. Also metal chelates, compositions, inks, printing processes, printed material and ink-jet cartridges.
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(2008/12/07)

N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-d iamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease
A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
Huang, Wenwei,Zheng, Wei,Urban, Daniel J.,Inglese, James,Sidransky, Ellen,Austin, Christopher P.,Thomas, Craig J.
p. 5783 - 5789
(2008/02/13)

Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer
The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
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(2008/06/13)

Triazine library with linkers
Triazine linkers can be used as universal small molecule chips for functional proteomics and sensors. These compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block.
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(2008/06/13)

Inhibitors of protein kinase for the treatment of disease
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.
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(2008/06/13)

Organic electroluminescent (EL) devices
A new class of conjugated organic polymers or copolymers comprising a triazine group. This class of polymers or copolymers may be used in organic electroluminescent (EL) devices.
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(2008/06/13)

Sodium channel drugs and uses
The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+channel, thereby modulating the biological activities thereof.
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(2008/06/13)

3-phenyl-pyrones
Novel 3-phenyl-pyrones of the formula in which A, D, X and Y are each as defined in the description, a process for preparing these substances and their use as pesticides, fungicides and herbicides.
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(2008/06/13)

Utilization of 3-phenyl-pyrones for pest control
3-Phenyl-pyrones of the formula in which x represents pyrid-2-yl and Y represents fluorine, or x represents 4-fluoro-phenyl and Y represents chlorine, are highly suitable for use as pesticides, fungicides and herbicides.
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(2008/06/13)

Arylphenyl-substituted cyclic keto enols
The present invention relates to novel arylphenyl-substituted cyclic ketoenols, their preparation and the use of such ketoenols as pesticides and/or herbicides. The novel arylphenyl-substituted cyclic ketoenols are of the formula (I) in which CKE refers to the cyclic ketoenol and W, X, Y and Z are as defined in the specification.
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(2008/06/13)

FLUORINATED ALKENYLTRIAZINES AND THEIR USE AS CROSSLINKING AGENTS
Disclosed herein are novel fluorinated vinyl and allyl substituted fluoroalkyl containing triazines and a process in which they are used as curing agents for the crosslinking of suitable fluoroelastomers. These polymers are useful in elastomeric seals and for other uses in which high temperature and/or chemical resistance is needed.
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(2008/06/13)

Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
The present invention relates to a radiolabeled non-steroidal compound having the formula: where R1, R2, and R3, are the same or different and are a radioactive or nonradioactive halogen, a nitro, a cyano, a carbamoyl, a hydrogen, a perfluoroalkyl, a haloalkylamido, an isothiocyanate, an azide, a diazocarbonyl, a substituted oxirane, or a beta -chloroethylamine; R4 is a hydrogen, an alkyl, or is joined to R5; R5 is a radioactive or nonradioactive halogen, a hydrogen, a hydroxy, an alkyl, a haloalkyl, an alkoxy, an acyloxy, an amino, an alkylamino, a thio, a thioalkyl, or is joined to R4; R6 is a hydrogen, an alkyl, a halogen, or a haloalkyl; A1 and A2 are the same or different, and each is a direct link or an alkylene; X1 is a radioactive or nonradioactive halogen, an oxygen, a sulfur, a sulphinyl, a sulphonyl, an amino, an alkylimino, or alkylene; R7 is a radioactive or nonradioactive halogen, a hydrogen, an alkoxy, a haloalkoxy, an acyloxy, a haloacyloxy, an aryloxy, a thioalkyl, a thioraryl, an alkylsulphinyl, an arylsulphinyl, an alkylsulphonyl, an arylsulphonyl, an amino, an alkylimino, an alkylamido group, a radioactive or nonradioactive haloalkylamido group, a phenyl optionally substituted with a radioactive or nonradioactive halogen, a nitro group, an alkyl, a radioactive or nonradioactive haloalkyl, a cyano, a hydroxyl, a carboxyl group, an amino, an alkylamino group, a dialkylamino group, a bisalkylamino group, a radioactive or nonradioactive haloalkylamino group, a radioactive or nonradioactive dihaloalkylamino group, a radioactive or nonradioactive bishaloalkylamino group, an acylamido group, a diacylamido group, an alkylacylamido group, a radioactive or nonradioactive haloacylamido group, a radioactive or nonradioactive bis(haloacyl)imido group, or a radioactive or nonradioactive alkylhaloacylamido group.
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(2008/06/13)

Halogen pyrimidines and its use thereof as parasite abatement means
PCT No. PCT/EP97/00151 Sec. 371 Date Jul. 16, 1998 Sec. 102(e) Date Jul. 16, 1998 PCT Filed Jan. 15, 1997 PCT Pub. No. WO97/27189 PCT Pub. Date Jul. 31, 1997Compounds of the formula (I) in which A represents optionally substituted alkanediyl, R represents in each case optionally substituted cycloalkyl, aryl or benzo-fused heterocyclyl, E represents -CH= or nitrogen, Q represents oxygen, sulphur, -CH2-O-, a single bond, or a nitrogen atom which is optionally substituted by alkyl, and X represents halogen.
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(2008/06/13)

Iminoacetic acid amides and their use as pest control agents
PCT No. PCT/EP96/04345 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 7, 1996 PCT Pub. No. WO97/14673 PCT Pub. Date Apr. 24, 1997Iminoacetamides of the formula (I) in which A represents a single bond or optionally substituted alkylene, Q represents oxygen or sulphur, R1 represents respectively optionally substituted cycloalkyl, cycloalkenyl, aryl or heterocyclyl, R2 represents respectively optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclyl, R3 represents hydrogen or respectively optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, R4 represents respectively optionally substituted cycloalkyl, cycloalkenyl, aryl or heterocyclcyl a process for their preparation, pesticidal compositions containing them, and their use for controlling pests.
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(2008/06/13)

Alkoxyacrylic acid thiol esters used as fungicides
PCT No. PCT/EP96/03436 Sec. 371 Date Feb. 10, 1998 Sec. 102(e) Date Feb. 10, 1998 PCT Filed Aug. 5, 1996 PCT Pub. No. WO97/07096 PCT Pub. Date Feb. 27, 1997The invention relates to novel alkoxyacrylic thiol esters, to a plurality of processes for their preparation and to their use as fungicides, and to novel intermediates and to a plurality of processes for their preparation.
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(2008/06/13)

Hydrazonoacetic acid amides and the use thereof as pesticides
The invention concerns hydrazonoacetic acid amides of general formula (I), a process for producing them, and the use of the said amides as pesticides. In the formula shown, the following meanings apply: A stands for a simple bond or optionally substituted alkylene; Q stands for oxygen or sulphur, R1 stands for optionally substituted cycloalkyl, cycloalkenyl, aryl or heterocyclyl; R2 stands for hydrogen or optionally substituted alkyl, cycloalkyl, cycloalkenyl, aryl or heterocyclyl; R3 and R4 are identical or different and each stand for hydrogen or optionally substituted alkyl or cycloalkyl; R2 and R3 together with the nitrogen atom to which they are bound form an optionally substituted heterocyclyl ring; R5 stands for optionally substituted cycloalkyl, cycloalkenyl, aryl or heterocyclyl.
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(2008/06/13)

Halogen alkenyl azolyl microbicides
Novel halogenoalkenyl-azolyl derivatives of the formula STR1 in which R1 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, optionally substituted aryl or represents optionally substituted heteroaryl, R2 represents alkyl, halogenoalkyl, 1-hydroxyalkyl, 2-hydroxyalkyl, 1-hydroxyhalogenalkyl, 1-alkenyl or 2-alkenyl, X1 represents fluorine, chlorine, bromine or iodine, X2 represents fluorine, chlorine, bromine or iodine, and Y represents nitrogen or a CH group, and addition products thereof with acids or metal salts are very active as microbicides in plant protection and in the protection of materials.
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(2008/06/13)

Substituted arylazadioxacyclo alkene fungicides
The invention relates to novel substituted arylazadioxacycloalkenes, a plurality of processes for their preparation and to their use as fungicides.
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(2008/06/13)

Preparation of asymmetrically substituted triazines
A process for preparing asymmetrically substituted triazines of the formula I STR1 where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II STR2 with a carboxylic acid derivative in the presence of an alcohol of the formula III which comprises reacting a carboxylic acid ester of the formula IV where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
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(2008/06/13)

Synergistic ultraviolet absorber compositions containing hydroxy aryl triazines and teraalkyl piperidines
A hydroxy group-containing aryl triazine ultraviolet absorber represented by the formula: STR1 wherein the R moiety of the OR group is a linear or branched aliphatic alkyl group containing 3 carbon atoms substituted by one or more alkoxy groups of 1 to 12 carbon atoms, said moiety being further substituted by one or more hydroxy groups, and wherein R19, R20, R21, R22, R23, R24 and R25 are independently selected from the group consisting of hydrogen, hydroxy, alkyl of 1 to 12 carbon atoms, alkoxy of 1 to 12 carbon atoms, sulfonic, halo, carboxy, haloalkyl and acrylamino.
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(2008/06/13)

Flame retardants
Compounds having a nucleus of general formula (I): in which:, n is an integer and has a value of at least 2;, R1 represents an alkyl group comprising up to 20 carbon atoms; and, R2 represents R3-
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(2008/06/13)

Synthesis of some new trisubstituted derivatives of 2,4,6-trichloro-1,3,5-triazine and their anti-bacterial activity
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Prakash,Tyagi,Mital,Mital
p. 284 - 284
(2007/10/02)

Method for control of hyperlipidemia
The present invention is directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: STR1 wherein R1 is hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C2 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R9 or --Y--CO--R9 ; R2 is STR2 R3 and R4 can be the same or different and are each the same as R1 ; R5, R6 and R7 can be the same or different and are each hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C1 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, --CO--R9, or --Y--CO--R9, with the proviso that R5 and R6 together cannot be so bulky as to cause the compound to decompose; R8 is hydrogen, a C1 to C5 alkyl, a C4 to C10 cycloalkyl, --CO--R9 or Y--CO--R9 ; R9 is hydrogen, a C1 to C5 alkyl or substituted alkyl, a C2 to C5 alkenyl or substituted alkenyl, a C2 to C5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C1 to C5 alkoxy or substituted alkoxy, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, --NHC6 C5l , --NR10 R11 wherein R10 and R11 can be the same or different and are each hydrogen, a C1 to C5 alkyl or substituted alkyl, phenyl or substituted phenyl; Y is a C1 to C10 alkylene or substituted alkylene; R12 is --CO, --COH, --CS, --CSH, or a C1 to C4 alkylene group; and and the pharmaceutically acceptable salts, and mixtures thereof.
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(2008/06/13)

6-substituted mitomycin analogs
Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, STR1 wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula --O--R, wherein R is: a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, and cyclo lower alkyl substituted lower alkyl; or a lower alkenyl radical; or a lower alkynyl radical; or a substituted or unsubstituted oxygen-containing heterocyclic radical selected from the group consisting of tetrahydro furanyl or lower alkyl substituted derivatives thereof, lower alkyl substituted oxiranyl, lower alkyl substituted dioxolanyl, lower alkyl substituted pyranyl, or lower alkyl substituted furanyl.
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(2008/06/13)

Photosensitive naphthoquinone diazide sulfonyl ester compounds for the fabrication of lithographic plates and photosensitive sheet construction with the compounds
The invention features a new series of triazine compounds which are characterized by their ability to generate free radicals upon irradiation in a desired optical region, such that they are useful in the fabrication of lithographic plates having improved exposure speed, development, print-out, and contrast characteristics.
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(2008/06/13)

2-amino-4-cyclopropyl-1,3,5-triazines as intermediates for the production of herbicidally active N-(cyclopropyl-triazinyl)-N'-arylsulfonyl ureas
2-Amino-4-cyclopropyl-1,3,5-triazines and processes for their production are disclosed. The 2-amino-4-cyclopropyl-1,3,5-triazines are intermediate in the production of herbicidally active N-(cyclopropyltriazinyl)-N'-arylsulfonyl ureas and correspond to the formula STR1 wherein R1 is hydrogen, C1 -C4 -alkyl or C1 -C4 -alkoxy, and R2 is C1 -C3 -alkyl, C1 -C3 -haloalkyl or C2 -C6 -alkoxyalkyl.
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(2008/06/13)

Process for the preparation of 2-arylamino-4,6-dichloro-s-triazines
In the preparation of a 2-arylamino-4,6-dichloro-s-triazine of the formula STR1 in which R1 is an optionally substituted aryl radical, and R2 is hydrogen or alkyl, by reacting cyanuric chloride of the formula STR2 with a virtually water-insoluble arylamine of the formula STR3 at a temperature between 0° and 100° C., the improvement which comprises effecting the reaction in water at an acid pH in the presence of a virtually water-insoluble organic solvent. The resulting aqueous phase contains the triazine in such high purity and concentration that it can be used without further purification. The organic solvent can be recycled.
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(2008/06/13)

Use of triazine derivatives for protecting maize and sorghum plants
There are described triazine derivatives of the formula I STR1 wherein R1, R2 and R3 independently of one another are each C1 -C5 -alkyl which is unsubstituted or monosubstituted by C3 -C6 -cycloalkyl, or mono- or polysubstituted by halogen, or is C3 -C6 - cycloalkyl which is unsubstituted or mono- or polysubstituted by halogen, or one of the substituents R1, R2 and R3 is also halogen or --NR4 R5, in which R4 is hydrogen or C1 -C5 -alkyl and R5 is hydrogen, C1 -C5 -alkyl, monochloroacetyl or dichloroacetyl. The triazine derivatives are used for the protection of maize and sorghum plants against the harmful effects of herbicidal chloroacetanilides and chloroacetamides.
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(2008/06/13)

N-(Cyclopropyl-triazinyl-n'-(arylsulfonyl) ureas having herbicidal activity
N-(Cyclopropyl-triazinyl- and -pyrimidinyl)-N'-arylsulfonyl ureas of the formula STR1 wherein Ar is a phenyl group STR2 or a naphthyl group STR3 and Q is a group X-A or R3, A is a C3 -C6 -alkynyl group, a C1 -C6 -alkyl group which is unsubstituted or substituted by halogen, C1 -C4 -alkoxy, C1 -C4 -alkylthio, C1 -C4 -alkylsulfinyl, C1 -C4 -alkylsulfonyl, C1 -C4 -haloalkoxy, C1 -C4 -haloalkylthio, C1 -C4 -haloalkylsulfinyl or C1 -C4 -haloalkylsulfonyl, or a C2 -C6 -alkenyl group which is unsubstituted or substituted by the groups given in the foregoing for C1 -C6 -alkyl, or A is a phenyl or benzyl group, E is the methine group or nitrogen, X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge, Z is oxygen or sulfur, R1 is hydrogen, C1 -C4 -alkyl or C1 -C4 -alkoxy, R2 is halogen, C1 -C3 -alkyl, C1 -C3 -haloalkyl, C1 -C3 -alkoxy, C1 -C3 -haloalkoxy, amino, C1 -C3 -alkylamino, di-(C1 -C3 -alkyl)amino, C3 -C6 -cycloalkyl or C2 -C6 -alkoxyalkyl, R3 is hydrogen, halogen, C1 -C5 -alkyl, C2 -C5 -alkenyl, C1 -C4 -haloalkyl, or a group --X-R6, --COZR11, --NO2 or --CO-NR8 R9, --CN, --COR10, --NR1 R7 or --NR1 -COR12, R4 is hydrogen, C1 -C4 -alkyl, C1 -C4 -alkoxy, C1 -C4 -alkylthio, C1 -C4 -haloalkyl, C1 -C4 -haloalkoxy, halogen, or alkoxyalkyl having at most 4 carbon atoms, R5 is the same as R3 but independent thereof, R6 and R7 are each C1 -C5 -alkyl, C2 -C5 -alkenyl or C2 -C6 -alkynyl, R8 and R9 independently of one another are each hydrogen, C1 -C5 -alkyl, C2 -C5 -alkenyl or C2 -C6 -alkynyl, R10 is hydrogen, C1 -C4 -alkyl or C1 -C3 -haloalkyl, R11 is hydrogen, C1 -C4 -alkyl, C1 -C3 -haloalkyl, C3 -C5 -alkenyl, C3 -C5 -alkynyl, phenyl or benzyl, and R12 is the same as R1 but independent thereof, and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with quaternary ammonium bases, have good pre- and post-emergence-selective herbicidal and plant-growth-regulating properties.
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(2008/06/13)

Agarose derivatives of amino phenyl boronic acid
Compound comprising agarose covalently bonded to amino phenyl boronic acid through a substituted triazine and an intermediate compound comprising substituted triazine bonded to amino phenyl boronic acid.
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(2008/06/13)

Piperidyl derivatives of triazine copolymers, processes for their preparation and stabilized composition containing these derivatives
The invention relates to a novel piperidine compounds which act as light stabilizers, heat stabilizers and oxidation stabilizers for synthetic polymers and have the general formula STR1 in which R1, R2, R3, R4, R5, R6, R7, A, B, X, Y, a and b are as defined in the specification. The compounds are particularly useful as light stabilizers for polyolefines in the form of fibres or film.
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(2008/06/13)

6-Aryl-4-hydrazinyl-s-triazin-2-ones
STR1 This invention relates to 6-aryl-4-hydrazinyl-1,2-dihydro-1,3,5-triazin-2-ones and 2-thiones of Formula I, processes for their preparation, intermediates useful in said processes and methods of treating physiological disorders in humans and animals, in particular, cardiovascular disorders, including hypertension.
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(2008/06/13)

4-Nitro-2-trichloromethylphenylsulfenamides
New 4-nitro-2-trichloromethylphenylsulfenamides having a fungicidal and bactericidal action, processes for their manufacture, fungicides containing these compounds as active ingredients, and a process for combating fungi with these compounds.
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(2008/06/13)

Antithrombotic 2-prenyl-3-oxo-5,6-diaryl-as-triazenes
The invention relates to compounds of the formula STR1 in which R and R' are identical or different and may be a hydrogen, an alkyl, a dialkylamino, an alkoxy, a halogen, or a hydroxy. These compounds are useful as drugs in the control of thromboses.
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(2008/06/13)

Cephalosporins
Cephalosporins represented by the formula X-S-Y wherein X is a deacetoxycephalosporinyl group and Y is a 6-membered heterocyclic group containing 1-3 nitrogens at least one of which is substituted and at least one of which is adjacent to a carbonyl group, said heterocyclic group containing one or more ring substituents and being characterized by being non-aromatic and not enolizable to an aromatic form.
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(2008/06/13)