- GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS
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The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
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Paragraph 00282
(2016/07/05)
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- Benzimidazole derivatives
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A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: 1wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents —COOR3, —SO3R3, —CONHR3 or —SO2NHR3, etc., G represents an alkylene group, M represents a single bond or —S(O)m. J represents a heterocyclic group, and X represents —CH= or a nitrogen atom.
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- Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure
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The invention relates to compounds of the formula I STR1 in which X, Y and Z are identical or different and are N or CR 2, R 1 and R 2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.
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- Reaction Pathways for the Cyclization of ortho-Thioalkyl and ortho-Thioaryl Substituted Phenyl Radicals with Alkynes. Reaction of o-Methylthioarenediazonium Tetrafluoroborates with Alkynes to give 2-Substituted Benzothiophenes
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An easily effected aromatic annelation is described involving reaction of o-thioalkyl and o-thioaryl substituted phenyl radicals with alkynes to give 2-substituted benzothiophenes; the mechanism is discussed.
- Leardini, Rino,Pedulli, Gian Franco,Tundo, Antonio,Zanardi, Giuseppe
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p. 1390 - 1391
(2007/10/02)
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