- Green synthesis of bis-coumarin derivatives using Fe(SD)3 as a catalyst and investigation of their biological activities
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A convenient, practical, green, and environmentally friendly method was developed for the synthesis of biscoumarins and corresponding tetrakis products from the reaction of 4-hydroxycoumarin and various aldehydes. The bis-coumarins were synthesized in hig
- Mahmoodi, Nosrat O.,Jalalifard, Zeinab,Fathanbari, Ghanbari Pirbasti
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p. 172 - 182
(2019/07/03)
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- Efficient synthesis of bis-(4-hydroxycoumarin) using sulfanilic acid as recyclable catalyst in water
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A catalytic reaction between aromatic aldehydes and 4- hydroxycoumarin has been developed to form a decent range of functionalized biscoumarin skeletons in excellent yields using sulfanilic acid as reusable catalyst in aqueous media. The catalytic reactio
- SADAT-JALALI, Mozhgan,MANAFI, Mohammadreza,HOMAMI, Seyed Saied,GORJI, Banafsheh,MONZAVI, Amirhossein
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p. 473 - 480
(2020/10/06)
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- Heterogeneous SO3H@Fe3O4 magnetic nanocatalyst as an efficient and reusable medium for the synthesis of 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, and 1,8-dioxo-octahydroxanthene derivatives
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This work aimed to synthesize a new heterogeneous catalyst (SO3H@Fe3O4 magnetic nanoparticles) and the study of its catalytic behavior in synthesizing 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, an
- Wu, Xiaobo,Peng, Wan-Xi
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p. 2129 - 2148
(2020/06/24)
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- Carbon-SO3H: An efficient catalyst for the synthesis of biscoumarin under ambient reaction conditions and their in silico studies
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In this article, we have established a highly promising approach for the synthesis of biscoumarins via domino Knoevenagel–Michael condensation of 4-hydroxycoumarin and aromatic aldehydes in 2:1 ratio using carbon-SO3H as a solid acid catalyst i
- Sethiya, Ayushi,Teli, Pankaj,Manhas, Anu,Agarwal, Dinesh,Soni, Jay,Sahiba, Nusrat,Jha, Prakash,Agarwal, Shikha
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supporting information
p. 2440 - 2460
(2020/07/10)
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- Aluminized Polyborate-catalyzed Environmentally Benign Solvent-free Protocol for the Synthesis of Bis-coumarin Derivatives
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The present work reports, an efficient application of aluminized polyborate as a mild solid acid catalyst for the multicomponent synthesis of biologically important bis-coumarin derivatives. The one-pot synthesis of bis-coumarins involves domino Knoevenag
- Aute, Dilip,Kshirsagar, Akshay,Kadnor, Vijay,Uphade, Bhagwat,Gadhave, Anil
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p. 599 - 605
(2021/01/25)
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- Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy
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The invention provides a coumarin compound, a preparation method, and an application of the coumarin compound in preparing medicines for treating cerebral apoplexy. The main purpose of the invention is to provide ideal ischemic stroke (IS) brain protection medicines conforming to partial or all standards, wherein the ideal IS brain protection medicines have a multi-layer effect (such as an antioxidant effect), can non-selectively block acute IS cascade reactions caused by oxidative stress (OS), can remarkably reduce the cerebral infarction volume, do not influence the vascular tension or cause bleeding events in research processes, promotes brain tissue to metabolize toxicity substances, have slight side effects, do not need differential diagnosis before being used, and consequentially make early-stage treatment efficient and feasible.
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-
Paragraph 0039-0046; 0052-0056
(2019/10/04)
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- A nano-composite of magnetite and hot-water-soluble starch: A cooperation resulting in an amplified catalytic activity on water
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Bis-coumarins and xanthenes are privileged compounds with diverse pharmaceutical activities. Hence, we introduce here an efficient synthesis of 3,3′-arylmethylene-bis-(4-hydroxycoumarin-3-yl) and 1,8-dioxooctahydroxanthenes under the soft catalytic activi
- Razikazemi, Sanaz,Rad-Moghadam, Kurosh,Toorchi-Roudsari, Saeedeh
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p. 12476 - 12485
(2018/08/04)
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- Efficient synthesis of bis(indolyl)methanes, bispyrazoles and biscoumarins using 4-sulfophthalic acid
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4-Sulfophthalic acid (4-H3SPA) solution 50?wt% in H2O has been effectively catalyzed the synthesis of a series of biologically relevant bis(indolyl)methanes by the electrophilic substitution of indole derivatives on aldehyde compound
- Banari, Hoda,Kiyani, Hamzeh,Pourali, Alireza
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p. 1635 - 1649
(2017/02/15)
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- BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives
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BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz
- Shirini, Farhad,Lati, Monireh Pourghasemi
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- Caffeine-H3PO4: a novel acidic catalyst for various one-pot multicomponent reactions
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Caffeine-H3PO4 along with caffeine-HClO4 and caffeine-HNO3 have been prepared and applied for one-pot preparation of bis(indolyl) methanes, 4,4′-(arylmethylene) bis(1H-pyrazol-5-ols), 3,3′-(arylmethylene) bis(4-hydroxycoumarins), 2,4,5-trisubstituted imidazoles, 1‐amidoalkyl‐2‐naphthols, and polyhydroquinolines. The catalysts were characterized using Fourier-transform infrared (FTIR) spectroscopy, 1H and 13C nuclear magnetic resonance (NMR), powder X-ray diffraction (PXRD) analysis, thermogravimetric analysis (TGA), and liquid chromatography (LC)–mass spectroscopy (MS) techniques. The results indicated high product yield, short reaction time, facile separation of catalyst, and easy work-up procedure, suggesting that caffeine-H3PO4 can be considered to be an efficient acidic catalyst for organic transformations.
- Saghanezhad, Seyyed Jafar,Sayahi, Mohammad Hosein,Imanifar, Iman,Mombeni, Mostafa,Deris Hamood, Sajedeh
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p. 6521 - 6536
(2017/10/06)
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- Highly efficient synthesis of dicoumarols and xanthene derivatives in presence of Br?nsted–Lewis acidic ionic liquids catalyst
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A series of metal chloride-based acidic ionic liquids have been prepared and used as an efficient catalyst in one-pot multicomponent synthesis of biscoumarins and substituted xanthenes derivatives under solvent-free conditions. Among the acidic ionic liqu
- Abbasi, Faezeh,Azizi, Najmedin,Abdoli-Senejani, Masumeh
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p. 2097 - 2103
(2017/09/13)
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- Synthesis of the first nanomagnetic particles with semicarbazide-based acidic ionic liquid tag: an efficient catalyst for the synthesis of 3,3′-(arylmethylene)bis(4-hydroxycoumarin) and 1-carbamato-alkyl-2-naphthol derivatives under mild and green conditi
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Semicarbazide functionalized with chlorosulfonic acid on the surface of silica-coated magnetic nanoparticles, {Fe3O4@SiO2@(CH2)3Semicarbazide-SO3H/HCl}, as a novel magnetic Br?nsted acid ca
- Zolfigol, Mohammad Ali,Ayazi-Nasrabadi, Roya,Baghery, Saeed
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p. 500 - 509
(2016/07/16)
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- A clean synthesis of bis(indolyl)methane and biscoumarin derivatives using P4VPy-CuO nanoparticles as a new, efficient and heterogeneous polymeric catalyst
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P4VPy-CuO nanoparticles as a novel solid catalyst were synthesized using an ultrasound irradiation method and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier Trans
- Shirini, Farhad,Fallah-Shojaei, Abdollah,Samavi, Laleh,Abedini, Masoumeh
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p. 48469 - 48478
(2016/06/09)
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- Ca(II)-catalyzed, one-pot four component synthesis of functionally embellished benzylpyrazolyl coumarins in water
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A facile one-pot, four-component synthesis of biologically important benzylpyrazolyl coumarins in water has been demonstrated using environmentally benign Ca(II) as the catalyst. Participation of aliphatic aldehydes has been described for the first time. Short reaction times, high yields and chromatography free isolation of the products, usage of eco-friendly catalyst and solvent are the key features of this method.
- Yaragorla, Srinivasarao,Pareek, Abhishek,Dada, Ravikrishna
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supporting information
p. 4770 - 4774
(2015/07/20)
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- Bronsted acidic ionic liquids of aza-crown ether complex cations: Preparation and applications in organic reactions
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A series of novel Bronsted acidic ionic liquids composed of an aza-crown ether chelated potassium cation and various anions, were designed, synthesized and characterised by FTIR, NMR and mass spectrometry, thermogravimetric differential thermal analysis (TG-DTA) and elemental analysis. These new Bronsted acidic ionic liquids of aza-crown ether complex cations (aCBAILs) were applied as catalysts to the Biginelli reaction, Mannich reaction and synthesis of bis-(4-hydroxycoumarin-3-yl)methanes. These organic reactions were achieved in good yields under mild reaction conditions. Moreover, these new IL catalysts can be recycled several times. This journal is the Partner Organisations 2014.
- Cheng, Chen,Jing, Huanwang
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p. 34325 - 34331
(2014/11/07)
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- Introduction of titania sulfonic acid (TiO2-SO3H) as a new, efficient, and reusable heterogenous solid acid catalyst for the synthesis of biscoumarins
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Titania sulfonic acid (TiO2-SO3H) is easily prepared by the reaction of TiO2 with neat chlorosulfonic acid and characterized using a variety of techniques, including infrared, X-ray diffraction, Brunauer-Emmett-Teller, sca
- Shirini, Farhad,Abedini, Masoumeh,Abroon Kiaroudi, Seddigheh
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p. 1279 - 1288
(2015/11/02)
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- Sulfonated rice husk ash (RHA-SO3H) as a highly efficient and reusable catalyst for the synthesis of some bis-heterocyclic compounds
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Sulfonated rice husk ash (RHA-SO3H), a newly reported solid acid catalyst, was efficiently used for the synthesis of 4,4′-(arylmethylene)- bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols), 3,3′-(arylmethylene)-bis-(4- hydroxycoumarins) and bis(indolyl)
- Seddighi, Mohadeseh,Shirini, Farhad,Mamaghani, Manouchehr
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p. 24046 - 24053
(2013/11/19)
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- Sulfated titania catalyzed water mediated efficient synthesis of dicoumarols - A green approach
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An efficient, mild, and environmental friendly method has been developed for the synthesis of dicoumarols in water over Lewis and Bronsted acid catalyst sulfated titania (TiO2/SO42-). The method involves the condensation of various aromatic and aliphatic aldehydes with 4-hydroxycoumarin. It affords the corresponding product in high yield with short reaction times employing a very low loading of catalyst. The catalyst was reused several times without significant change in activity.
- Karmakar, Bikash,Nayak, Anupam,Banerji, Julie
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experimental part
p. 4343 - 4346
(2012/09/22)
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- Tris(hydrogensulfato) boron as a solid heterogeneous catalyst for the rapid synthesis of α,α′-benzylidene bis(4-hydroxycoumarin) derivatives
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α,α′-Benzylidene bis(4-hydroxycoumarin) derivatives were readily prepared in a few minutes with good yields through the reaction of an aromatic aldehyde and 4-hydroxycoumarin in aqueous media in the presence of catalytic tris(hydrogensulfato) boron [B(HSO
- Karimi-Jaberi, Zahed,Nazarifar, Mohammad Reza,Pooladian, Baharak
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experimental part
p. 781 - 784
(2012/08/28)
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- Biscoumarin: New class of urease inhibitors; Economical synthesis and activity
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A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06-91.35 μM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.
- Khan, Khalid Mohammed,Iqbal, Sajid,Lodhi, Muhammad Arif,Maharvi, Ghulam Murtaza,Zia-Ullah,Choudhary, Muhammad Iqbal,Atta-ur-Rahman,Perveen, Shahnaz
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p. 1963 - 1968
(2007/10/03)
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