- An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O
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Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].
- Bhat, Prabhat,Shridhar, Gomathi,Ladage, Savita,Ravishankar, Lakshmy
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p. 1441 - 1448
(2017/09/25)
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- Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst
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Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.
- Nasr-Esfahani, Masoud,Daghaghale, Mona,Taei, Mahbube
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- A convenient and efficient protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines in acetic acid under ultrasound irradiation
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1,3,5-Triaryl-2-pyrazolines were synthesized in acetic acid in high yields within 60-180 min under ultrasound irradiation at room temperature.
- Lin, Zhi-Ping,Li, Ji-Tai
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experimental part
p. 267 - 271
(2012/06/18)
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- Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines
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A series of 1,3,5-triaryl-2-pyrazolines 2a-g were synthesized by the reaction of 4,40-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized produc
- Samshuddin, Seranthimata,Narayana, Badiadka,Sarojini, Balladka Kunhanna,Raj, Chenna Govindaraju Darshan,Khan, Mahmud Tareq Hassan,Yathirajan, Hemmige S.,Raghavendra, Ramappa
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p. 2012 - 2022,11
(2020/07/30)
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- Mechanically activated synthesis of 1,3,5-triaryl-2-pyrazolines by high speed ball milling
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An efficient mechanically activated solvent-free synthesis of 1,3,5-triaryl-2-pyrazolines from chalcones and phenylhydrazines using high speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time and ne
- Zhu, Xingyi,Li, Zhenhua,Jin, Can,Xu, Li,Wu, Qianqian,Su, Weike
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experimental part
p. 163 - 165
(2010/04/22)
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- Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition
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A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 n
- Wang, Yizhong,Rivera Vera, Claudia I.,Lin, Qing
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p. 4155 - 4158
(2008/02/12)
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- Synthesis of pyrazoline and isoxazoline in triethanolamine medium
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Reactions of chalcones 1a-u with phenylhydrazine and hydrazine hydrate give pyrazolines 2a-u and with hydroxylamine hydrochloride yield isoxazolines 3a-c in triethanolamine medium. The structures of products are established by melting points, chemical studies and spectral data (IR and 1HNMR).
- Agrawal, Nitin N.,Soni
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p. 2700 - 2701
(2007/10/03)
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- Syntheses and Spectroscopic Characterisation of Some New 3,5-Bisaryl-2-pyrazoline Derivatives. II
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Durch Kondensation von Hydrazin bzw. substituierten Hydrazinen mit Chalkonen wurden einige neue 3,5-bisarylierte-2-pyrazoline 4, 7-18 dargestellt.Bromierung des Pyrazolins 4 liefert das 4-Brompyrazol 20.Die Verbindungen wurden durch hochaufloesende Massen
- Sayed, G. H.,Kjosen, H.
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p. 716 - 722
(2007/10/02)
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